An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues
Ethacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high blood pressure and the swelling caused by diseases such as congestive heart failure, liver failure, and kidney failure. EA has an α,β-unsaturated carbonyl unit which acts as a Michael acceptor involved in the i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623003569 |
| _version_ | 1797398627940827136 |
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| author | Nabil El Brahmi Abdelmoula El Abbouchi Saïd El Kazzouli |
| author_facet | Nabil El Brahmi Abdelmoula El Abbouchi Saïd El Kazzouli |
| author_sort | Nabil El Brahmi |
| collection | DOAJ |
| description | Ethacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high blood pressure and the swelling caused by diseases such as congestive heart failure, liver failure, and kidney failure. EA has an α,β-unsaturated carbonyl unit which acts as a Michael acceptor involved in the inhibition of the major classes of glutathione S-transferases (GSTs) (α, μ, and π) that plays a crucial role in regulating the multidrug resistance. Moreover, EA was used as an adjuvant to improve the therapeutic efficacy of several anticancer chemotherapeutic agents. EA and their derivatives have received considerable attention in the past decades due to their interesting biological properties. This review highlights the recent development in this area, focusing on their synthesis and their antitumor activities. |
| first_indexed | 2024-03-09T01:28:17Z |
| format | Article |
| id | doaj.art-6ea7bcd1c8884d8cb57801f35baa55fd |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T01:28:17Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-6ea7bcd1c8884d8cb57801f35baa55fd2023-12-10T06:15:18ZengElsevierResults in Chemistry2211-71562023-12-016101117An overview on the synthesis and anticancer properties of ethacrynic acid and their analoguesNabil El Brahmi0Abdelmoula El Abbouchi1Saïd El Kazzouli2Euromed Research Center, Euromed Faculty of Pharmacy and School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, 30000 Fez, MoroccoEuromed Research Center, Euromed Faculty of Pharmacy and School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, 30000 Fez, MoroccoCorresponding author.; Euromed Research Center, Euromed Faculty of Pharmacy and School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, 30000 Fez, MoroccoEthacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high blood pressure and the swelling caused by diseases such as congestive heart failure, liver failure, and kidney failure. EA has an α,β-unsaturated carbonyl unit which acts as a Michael acceptor involved in the inhibition of the major classes of glutathione S-transferases (GSTs) (α, μ, and π) that plays a crucial role in regulating the multidrug resistance. Moreover, EA was used as an adjuvant to improve the therapeutic efficacy of several anticancer chemotherapeutic agents. EA and their derivatives have received considerable attention in the past decades due to their interesting biological properties. This review highlights the recent development in this area, focusing on their synthesis and their antitumor activities.http://www.sciencedirect.com/science/article/pii/S2211715623003569Ethacrynic acidDiureticGlutathione-S-transferaseAnti-proliferative activityαβ-unsaturated carbonyl |
| spellingShingle | Nabil El Brahmi Abdelmoula El Abbouchi Saïd El Kazzouli An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues Results in Chemistry Ethacrynic acid Diuretic Glutathione-S-transferase Anti-proliferative activity α β-unsaturated carbonyl |
| title | An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| title_full | An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| title_fullStr | An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| title_full_unstemmed | An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| title_short | An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| title_sort | overview on the synthesis and anticancer properties of ethacrynic acid and their analogues |
| topic | Ethacrynic acid Diuretic Glutathione-S-transferase Anti-proliferative activity α β-unsaturated carbonyl |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623003569 |
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