Rational Design of Profile HMMs for Sensitive and Specific Sequence Detection with Case Studies Applied to Viruses, Bacteriophages, and Casposons

Profile hidden Markov models (HMMs) are a powerful way of modeling biological sequence diversity and constitute a very sensitive approach to detecting divergent sequences. Here, we report the development of protocols for the rational design of profile HMMs. These methods were implemented on TABAJARA...

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Bibliographic Details
Main Authors:	Liliane S. Oliveira, Alejandro Reyes, Bas E. Dutilh, Arthur Gruber
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Viruses
Subjects:	viral classification viral detection profile HMMs sequence classes mutual information theory sequence entropy
Online Access:	https://www.mdpi.com/1999-4915/15/2/519

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