Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know
With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/12/1/17 |
| _version_ | 1797344289099874304 |
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| author | Sali Al-Ansari Juliette Stolze Dorine Bresters Alan Henry Brook Alexa M. G. A. Laheij Henk S. Brand Göran Dahllöf Frederik R. Rozema Judith E. Raber-Durlacher |
| author_facet | Sali Al-Ansari Juliette Stolze Dorine Bresters Alan Henry Brook Alexa M. G. A. Laheij Henk S. Brand Göran Dahllöf Frederik R. Rozema Judith E. Raber-Durlacher |
| author_sort | Sali Al-Ansari |
| collection | DOAJ |
| description | With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from damage caused by their cancer treatment to endocrine, cardiovascular, musculoskeletal, and other organ systems. These complications may surface decades after the completion of treatment. Adverse outcomes of childhood cancer treatment frequently involve oral and craniofacial structures including the dentition. Tooth development, salivary gland function, craniofacial growth, and temporomandibular joint function may be disturbed, increasing oral health risks in these individuals. Moreover, CCS are at risk of developing subsequent malignancies, which may manifest in or near the oral cavity. It is important that dental practitioners are aware of the childhood cancer history of their patients and have knowledge of potential late complications. Therefore, this narrative review aims to inform dental practitioners of late oral complications of cancer treatment modalities commonly used in pediatric oncology. Furthermore, selected common non-oral late sequelae of cancer therapy that could have an impact on oral health and on delivering dental care will be discussed. |
| first_indexed | 2024-03-08T11:01:12Z |
| format | Article |
| id | doaj.art-6ea8560ee3684c8a8ea9a093f177b1ae |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-08T11:01:12Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-6ea8560ee3684c8a8ea9a093f177b1ae2024-01-26T16:00:01ZengMDPI AGDentistry Journal2304-67672024-01-011211710.3390/dj12010017Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to KnowSali Al-Ansari0Juliette Stolze1Dorine Bresters2Alan Henry Brook3Alexa M. G. A. Laheij4Henk S. Brand5Göran Dahllöf6Frederik R. Rozema7Judith E. Raber-Durlacher8Department of Oral Medicine, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsDepartment of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsAdelaide Dental School, University of Adelaide, Adelaide 5005, AustraliaDepartment of Oral Medicine, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsDepartment of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsDivision of Orthodontics and Pediatric Dentistry, Karolinska Institutet, 14152 Huddinge, SwedenDepartment of Oral Medicine, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsDepartment of Oral Medicine, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The NetherlandsWith diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from damage caused by their cancer treatment to endocrine, cardiovascular, musculoskeletal, and other organ systems. These complications may surface decades after the completion of treatment. Adverse outcomes of childhood cancer treatment frequently involve oral and craniofacial structures including the dentition. Tooth development, salivary gland function, craniofacial growth, and temporomandibular joint function may be disturbed, increasing oral health risks in these individuals. Moreover, CCS are at risk of developing subsequent malignancies, which may manifest in or near the oral cavity. It is important that dental practitioners are aware of the childhood cancer history of their patients and have knowledge of potential late complications. Therefore, this narrative review aims to inform dental practitioners of late oral complications of cancer treatment modalities commonly used in pediatric oncology. Furthermore, selected common non-oral late sequelae of cancer therapy that could have an impact on oral health and on delivering dental care will be discussed.https://www.mdpi.com/2304-6767/12/1/17pediatric cancerchildhood cancer survivorslate effectschronic oral complicationsoral caredental treatment |
| spellingShingle | Sali Al-Ansari Juliette Stolze Dorine Bresters Alan Henry Brook Alexa M. G. A. Laheij Henk S. Brand Göran Dahllöf Frederik R. Rozema Judith E. Raber-Durlacher Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know Dentistry Journal pediatric cancer childhood cancer survivors late effects chronic oral complications oral care dental treatment |
| title | Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know |
| title_full | Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know |
| title_fullStr | Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know |
| title_full_unstemmed | Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know |
| title_short | Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know |
| title_sort | late complications in long term childhood cancer survivors what the oral health professional needs to know |
| topic | pediatric cancer childhood cancer survivors late effects chronic oral complications oral care dental treatment |
| url | https://www.mdpi.com/2304-6767/12/1/17 |
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