Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study
Abstract Objective Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, stud...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-021-05595-8 |
| _version_ | 1819088512595525632 |
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| author | Gamilah Al-Qadhi Rabab Mubarak |
| author_facet | Gamilah Al-Qadhi Rabab Mubarak |
| author_sort | Gamilah Al-Qadhi |
| collection | DOAJ |
| description | Abstract Objective Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope. Results Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria. |
| first_indexed | 2024-12-21T21:53:13Z |
| format | Article |
| id | doaj.art-6eaa42f48c3b4a158bd25ab7c4922aae |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-21T21:53:13Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-6eaa42f48c3b4a158bd25ab7c4922aae2022-12-21T18:49:02ZengBMCBMC Research Notes1756-05002021-05-011411710.1186/s13104-021-05595-8Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo studyGamilah Al-Qadhi0Rabab Mubarak1Department of Basic Dental Sciences, Faculty of Dentistry, University of Science and TechnologyDepartment of Oral Biology, Faculty of Dentistry, Cairo UniversityAbstract Objective Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope. Results Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria.https://doi.org/10.1186/s13104-021-05595-8KhatCatha edulisSubmandibular salivary glandUltrastructural changesTEM |
| spellingShingle | Gamilah Al-Qadhi Rabab Mubarak Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study BMC Research Notes Khat Catha edulis Submandibular salivary gland Ultrastructural changes TEM |
| title | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
| title_full | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
| title_fullStr | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
| title_full_unstemmed | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
| title_short | Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study |
| title_sort | qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat in vivo study |
| topic | Khat Catha edulis Submandibular salivary gland Ultrastructural changes TEM |
| url | https://doi.org/10.1186/s13104-021-05595-8 |
| work_keys_str_mv | AT gamilahalqadhi qualitativeultrastructuralanalysisofthesubmandibularsalivaryglandsafteradministrationofkhatinvivostudy AT rababmubarak qualitativeultrastructuralanalysisofthesubmandibularsalivaryglandsafteradministrationofkhatinvivostudy |