Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan
Background & Objective: One of the most prevalent types of cancer among women is breast cancer. The objective of this study is to compare the serum level of tumor marker of Carcinoembryonic Antigen (CEA), Prolactin, and oxidative marker Malondialdehyde (MDA) in patients with breast cancer and in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2014-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-180-en.pdf |
| _version_ | 1797679693501038592 |
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| author | Sana Taghiyar Kahin Shahanipoor Nemat al Razmi |
| author_facet | Sana Taghiyar Kahin Shahanipoor Nemat al Razmi |
| author_sort | Sana Taghiyar |
| collection | DOAJ |
| description | Background & Objective: One of
the most prevalent types of cancer among women is breast cancer. The objective
of this study is to compare the serum level of tumor marker of Carcinoembryonic
Antigen (CEA), Prolactin, and oxidative marker Malondialdehyde (MDA) in
patients with breast cancer and in control groups.
Materials & Methods: This case control study was carried out on the people
who went to Seyedo Shohada Hospital in Isfahan. The experimental group was
composed of 44 patients with breast cancer who were under treatment and the
control group consisted of 44 healthy people. The amount of CEA and Prolactin
was measured via ELISA, while the measurement of MDA was made manually and on
the basis of reaction to Thiobarbituric acid.
Results: The results of the current study indicated that the mean
concentration of CEA in patients with breast cancer (2.175 ± 1.78ng/ml) was
significantly greater than that of healthy people (1.161 ± 0.85ng/ml) (P <
0.001). The mean concentration of prolactin in patients with breast cancer and
in healthy people were not significantly different, and the mean concentration
of MDA of the patients with breast cancer (1.44 ± 0.37µ mol/dl ) was significantly greater than that
of the healthy people(1.27 ± 0.25µ mol/dl ) (P < 0.01.(
Conclusion: CEA can be used as a valuable serum marker in the efficacy of the
treatment procedure as well as the diagnosis of metastatic breast cancer.
Moreover, the role of lipid peroxidation as an effective process in the
formation of breast cancer was confirmed. |
| first_indexed | 2024-03-11T23:17:32Z |
| format | Article |
| id | doaj.art-6eab81d534cc485fb80757bb03a02d0e |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:32Z |
| publishDate | 2014-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-6eab81d534cc485fb80757bb03a02d0e2023-09-20T21:17:46ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232014-11-0143362370Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in IsfahanSana Taghiyar0Kahin Shahanipoor1Nemat al Razmi2 Department of Biochemistry, Islamic Azad University, Fars Science and Research Branch, Fars, Iran. Department of Biochemistry, Islamic Azad University, Falavarjan Branch, Isfahan, Iran. Department of Biochemistry, Islamic Azad University, Fars Science and Research Branch, Fars, Iran. Background & Objective: One of the most prevalent types of cancer among women is breast cancer. The objective of this study is to compare the serum level of tumor marker of Carcinoembryonic Antigen (CEA), Prolactin, and oxidative marker Malondialdehyde (MDA) in patients with breast cancer and in control groups. Materials & Methods: This case control study was carried out on the people who went to Seyedo Shohada Hospital in Isfahan. The experimental group was composed of 44 patients with breast cancer who were under treatment and the control group consisted of 44 healthy people. The amount of CEA and Prolactin was measured via ELISA, while the measurement of MDA was made manually and on the basis of reaction to Thiobarbituric acid. Results: The results of the current study indicated that the mean concentration of CEA in patients with breast cancer (2.175 ± 1.78ng/ml) was significantly greater than that of healthy people (1.161 ± 0.85ng/ml) (P < 0.001). The mean concentration of prolactin in patients with breast cancer and in healthy people were not significantly different, and the mean concentration of MDA of the patients with breast cancer (1.44 ± 0.37µ mol/dl ) was significantly greater than that of the healthy people(1.27 ± 0.25µ mol/dl ) (P < 0.01.( Conclusion: CEA can be used as a valuable serum marker in the efficacy of the treatment procedure as well as the diagnosis of metastatic breast cancer. Moreover, the role of lipid peroxidation as an effective process in the formation of breast cancer was confirmed.http://jabs.fums.ac.ir/article-1-180-en.pdfbreast cancerceaprolactinmalondialdehyde |
| spellingShingle | Sana Taghiyar Kahin Shahanipoor Nemat al Razmi Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan Journal of Advanced Biomedical Sciences breast cancer cea prolactin malondialdehyde |
| title | Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan |
| title_full | Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan |
| title_fullStr | Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan |
| title_full_unstemmed | Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan |
| title_short | Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan |
| title_sort | comparison of the serum level of carcinoembryonic antigen prolactin and malondialdehyde in patients suffering from breast cancer and in healthy individuals in isfahan |
| topic | breast cancer cea prolactin malondialdehyde |
| url | http://jabs.fums.ac.ir/article-1-180-en.pdf |
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