AFF3 upregulation mediates tamoxifen resistance in breast cancers

AFF3 upregulation mediates tamoxifen resistance in breast cancers

Abstract Background Although tamoxifen is a highly effective drug for treating estrogen receptor–positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acquired drug resistance. Unfortunately, few molecular mediators of tam...

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Bibliographic Details
Main Authors: Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming Wang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
AFF3
Breast cancer
Estrogen receptor-positive
Tamoxifen
Resistance
Online Access:http://link.springer.com/article/10.1186/s13046-018-0928-7

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