The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 Stimulation

The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 Stimulation

The NK cell exhaustion state evolving during extensive and prolonged cultivation is still one of the limitations of NK cell approaches. In this research, we transduced NK cells with the <i>hTERT</i> and <i>iCasp9</i> genes. hTERT overexpression can prevent the functional exha...

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Bibliographic Details
Main Authors: Anastasia I. Palamarchuk, Elena I. Kovalenko, Maria A. Streltsova
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
NK cells
EOMES
T-BET
<i>hTERT</i>
<i>iCasp9</i>
stimulation
Online Access:https://www.mdpi.com/2227-9059/12/3/650

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