Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report
Introduction: Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune neurological disorder and is diagnosed by GFAP-IgG in cerebrospinal fluid (CSF) measurement. Case report: Herein, we described a 10-year-old boy with abnormal neurological symptoms and signs. GFAP-IgG was detec...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024028585 |
| _version_ | 1797259863095508992 |
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| author | Ya Guo Jiamin Guo Xueyu Wang Aihua Ma Yuxing Gao Jiacheng Chen Cuili Nie Na Chen |
| author_facet | Ya Guo Jiamin Guo Xueyu Wang Aihua Ma Yuxing Gao Jiacheng Chen Cuili Nie Na Chen |
| author_sort | Ya Guo |
| collection | DOAJ |
| description | Introduction: Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune neurological disorder and is diagnosed by GFAP-IgG in cerebrospinal fluid (CSF) measurement. Case report: Herein, we described a 10-year-old boy with abnormal neurological symptoms and signs. GFAP-IgG was detected in CSF using cell-based assay (CBA), and his CSF showed an increase in lymphocytes, a slight decrease in glucose and an increase in protein level in the early stage. The cranial MRI showed multiple strips of T2-FLAIR hyperintense signal changes on the surface of medulla oblongata, pons, and gyrus in bilateral cerebral hemispheres. He was treated with immunoglobulin (IVIG) and high-dose methylprednisolone pulse treatment, and his clinical presentations gradually improved. Conclusion: We highlight that patients with normal inflammatory markers in peripheral blood have obvious meningitis-like symptoms, and clinicians need to consider GFAP astrocytopathy. The early diagnosis and treatment of GFAP astrocytopathy are important for improving the prognosis. |
| first_indexed | 2024-03-07T20:04:07Z |
| format | Article |
| id | doaj.art-6eaea5d1182148d8a9704287d3260290 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:16:11Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6eaea5d1182148d8a9704287d32602902024-03-17T07:56:24ZengElsevierHeliyon2405-84402024-03-01105e26827Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case reportYa Guo0Jiamin Guo1Xueyu Wang2Aihua Ma3Yuxing Gao4Jiacheng Chen5Cuili Nie6Na Chen7Department of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaCorresponding author.; Department of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, ChinaIntroduction: Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune neurological disorder and is diagnosed by GFAP-IgG in cerebrospinal fluid (CSF) measurement. Case report: Herein, we described a 10-year-old boy with abnormal neurological symptoms and signs. GFAP-IgG was detected in CSF using cell-based assay (CBA), and his CSF showed an increase in lymphocytes, a slight decrease in glucose and an increase in protein level in the early stage. The cranial MRI showed multiple strips of T2-FLAIR hyperintense signal changes on the surface of medulla oblongata, pons, and gyrus in bilateral cerebral hemispheres. He was treated with immunoglobulin (IVIG) and high-dose methylprednisolone pulse treatment, and his clinical presentations gradually improved. Conclusion: We highlight that patients with normal inflammatory markers in peripheral blood have obvious meningitis-like symptoms, and clinicians need to consider GFAP astrocytopathy. The early diagnosis and treatment of GFAP astrocytopathy are important for improving the prognosis.http://www.sciencedirect.com/science/article/pii/S2405844024028585GFAP astrocytopathyMeningitisCSFMRITreatment |
| spellingShingle | Ya Guo Jiamin Guo Xueyu Wang Aihua Ma Yuxing Gao Jiacheng Chen Cuili Nie Na Chen Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report Heliyon GFAP astrocytopathy Meningitis CSF MRI Treatment |
| title | Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report |
| title_full | Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report |
| title_fullStr | Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report |
| title_full_unstemmed | Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report |
| title_short | Glial fibrillary acidic protein astrocytopathy presented as meningitis: A case report |
| title_sort | glial fibrillary acidic protein astrocytopathy presented as meningitis a case report |
| topic | GFAP astrocytopathy Meningitis CSF MRI Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024028585 |
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