Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29420-3 |
| _version_ | 1811272993915011072 |
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| author | Federica Schiavoni Pedro Zuazua-Villar Theodoros I. Roumeliotis Graeme Benstead-Hume Mercedes Pardo Frances M. G. Pearl Jyoti S. Choudhary Jessica A. Downs |
| author_facet | Federica Schiavoni Pedro Zuazua-Villar Theodoros I. Roumeliotis Graeme Benstead-Hume Mercedes Pardo Frances M. G. Pearl Jyoti S. Choudhary Jessica A. Downs |
| author_sort | Federica Schiavoni |
| collection | DOAJ |
| description | Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the SWI/SNF chromatin remodelling complex is frequently lost in cancer. Here, the authors show that BRG1 loss can lead to changes that allow tolerance to aneuploidy. This creates a setting where karyotype changes can be explored without a fitness penalty, allowing adaptation to changing environments. This could play an important role in the progression of BRG1 deficient cancers. |
| first_indexed | 2024-04-12T22:50:16Z |
| format | Article |
| id | doaj.art-6eaf790b03964eb082453da384012a47 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T22:50:16Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6eaf790b03964eb082453da384012a472022-12-22T03:13:22ZengNature PortfolioNature Communications2041-17232022-04-0113111510.1038/s41467-022-29420-3Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitnessFederica Schiavoni0Pedro Zuazua-Villar1Theodoros I. Roumeliotis2Graeme Benstead-Hume3Mercedes Pardo4Frances M. G. Pearl5Jyoti S. Choudhary6Jessica A. Downs7Epigenetics and Genome Stability Team, The Institute of Cancer ResearchEpigenetics and Genome Stability Team, The Institute of Cancer ResearchFunctional Proteomics Team, The Institute of Cancer ResearchFunctional Proteomics Team, The Institute of Cancer ResearchFunctional Proteomics Team, The Institute of Cancer ResearchBioinformatics Group, School of Life Sciences, University of SussexFunctional Proteomics Team, The Institute of Cancer ResearchEpigenetics and Genome Stability Team, The Institute of Cancer ResearchAneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the SWI/SNF chromatin remodelling complex is frequently lost in cancer. Here, the authors show that BRG1 loss can lead to changes that allow tolerance to aneuploidy. This creates a setting where karyotype changes can be explored without a fitness penalty, allowing adaptation to changing environments. This could play an important role in the progression of BRG1 deficient cancers.https://doi.org/10.1038/s41467-022-29420-3 |
| spellingShingle | Federica Schiavoni Pedro Zuazua-Villar Theodoros I. Roumeliotis Graeme Benstead-Hume Mercedes Pardo Frances M. G. Pearl Jyoti S. Choudhary Jessica A. Downs Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness Nature Communications |
| title | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness |
| title_full | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness |
| title_fullStr | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness |
| title_full_unstemmed | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness |
| title_short | Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness |
| title_sort | aneuploidy tolerance caused by brg1 loss allows chromosome gains and recovery of fitness |
| url | https://doi.org/10.1038/s41467-022-29420-3 |
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