The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency

The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency

Objective: The newly defined cancer-testis (CT) gene, MEIOB, was previously found to play key roles in DNA double-strand break (DSB) repair. In this study, we aimed to investigate the effects and mechanisms of MEIOB in the carcinogenesis of triple-negative breast cancers (TNBCs). Methods: The Cancer...

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Bibliographic Details
Main Authors: Yayun Gu, Cheng Wang, Rongxuan Zhu, Jianshui Yang, Wenwen Yuan, Yanhui Zhu, Yan Zhou, Na Qin, Hongbing Shen, Hongxia Ma, Hongxia Wang, Xiaoan Liu, Zhibin Hu
Format: Article
Language:English
Published: China Anti-Cancer Association 2021-02-01
Series:Cancer Biology & Medicine
Subjects:
cancer-testis gene
meiob
triple-negative breast cancer
parp1 inhibitor
cell proliferation
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1772

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