Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma
Glioblastoma (GBM) is the most aggressive form of glioma tumor in adult brain. Among the numerous factors responsible for GBM cell proliferation and invasion, neurotransmitters such as dopamine, serotonin and glutamate can play key roles. Studies performed in mice housed in germ-free (GF) conditions...
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/11/2810 |
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| author | Giuseppina D’Alessandro Clotilde Lauro Deborah Quaglio Francesca Ghirga Bruno Botta Flavia Trettel Cristina Limatola |
| author_facet | Giuseppina D’Alessandro Clotilde Lauro Deborah Quaglio Francesca Ghirga Bruno Botta Flavia Trettel Cristina Limatola |
| author_sort | Giuseppina D’Alessandro |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most aggressive form of glioma tumor in adult brain. Among the numerous factors responsible for GBM cell proliferation and invasion, neurotransmitters such as dopamine, serotonin and glutamate can play key roles. Studies performed in mice housed in germ-free (GF) conditions demonstrated the relevance of the gut-brain axis in a number of physiological and pathological conditions. The gut–brain communication is made possible by vagal/nervous and blood/lymphatic routes and pave the way for reciprocal modulation of functions. The gut microbiota produces and consumes a wide range of molecules, including neurotransmitters (dopamine, norepinephrine, serotonin, gamma-aminobutyric acid [GABA], and glutamate) that reach their cellular targets through the bloodstream. Growing evidence in animals suggests that modulation of these neurotransmitters by the microbiota impacts host neurophysiology and behavior, and affects neural cell progenitors and glial cells, along with having effects on tumor cell growth. In this review we propose a new perspective connecting neurotransmitter modulation by gut microbiota to glioma progression. |
| first_indexed | 2024-03-10T10:42:00Z |
| format | Article |
| id | doaj.art-6eb02ae02ce34eab89b7c1a099f4ac0e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:42:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6eb02ae02ce34eab89b7c1a099f4ac0e2023-11-21T22:50:55ZengMDPI AGCancers2072-66942021-06-011311281010.3390/cancers13112810Neuro-Signals from Gut Microbiota: Perspectives for Brain GliomaGiuseppina D’Alessandro0Clotilde Lauro1Deborah Quaglio2Francesca Ghirga3Bruno Botta4Flavia Trettel5Cristina Limatola6Department of Physiology and Pharmacology, Sapienza University, 00185 Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University, 00185 Rome, ItalyIRCCS Neuromed, 86077 Pozzilli, IS, ItalyGlioblastoma (GBM) is the most aggressive form of glioma tumor in adult brain. Among the numerous factors responsible for GBM cell proliferation and invasion, neurotransmitters such as dopamine, serotonin and glutamate can play key roles. Studies performed in mice housed in germ-free (GF) conditions demonstrated the relevance of the gut-brain axis in a number of physiological and pathological conditions. The gut–brain communication is made possible by vagal/nervous and blood/lymphatic routes and pave the way for reciprocal modulation of functions. The gut microbiota produces and consumes a wide range of molecules, including neurotransmitters (dopamine, norepinephrine, serotonin, gamma-aminobutyric acid [GABA], and glutamate) that reach their cellular targets through the bloodstream. Growing evidence in animals suggests that modulation of these neurotransmitters by the microbiota impacts host neurophysiology and behavior, and affects neural cell progenitors and glial cells, along with having effects on tumor cell growth. In this review we propose a new perspective connecting neurotransmitter modulation by gut microbiota to glioma progression.https://www.mdpi.com/2072-6694/13/11/2810gliomamicrobiotagut-brain axisneurotransmitterscell proliferation |
| spellingShingle | Giuseppina D’Alessandro Clotilde Lauro Deborah Quaglio Francesca Ghirga Bruno Botta Flavia Trettel Cristina Limatola Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma Cancers glioma microbiota gut-brain axis neurotransmitters cell proliferation |
| title | Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma |
| title_full | Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma |
| title_fullStr | Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma |
| title_full_unstemmed | Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma |
| title_short | Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma |
| title_sort | neuro signals from gut microbiota perspectives for brain glioma |
| topic | glioma microbiota gut-brain axis neurotransmitters cell proliferation |
| url | https://www.mdpi.com/2072-6694/13/11/2810 |
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