The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018
Background & Objective Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated the relationship between selenium and non-alcoholic fatty liver disease (NAFLD) and fibrosis, these findings were still inconclusive. Ou...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2110277 |
| _version_ | 1828424440008933376 |
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| author | Jie Liu Liao Tan Zhaoya Liu Ruizheng Shi |
| author_facet | Jie Liu Liao Tan Zhaoya Liu Ruizheng Shi |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Background & Objective Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated the relationship between selenium and non-alcoholic fatty liver disease (NAFLD) and fibrosis, these findings were still inconclusive. Our study was aimed to explore the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by vibration controlled transient elastography (VCTE) in US adults.Methods All data were extracted from National Health and Nutrition Examination Survey database (2017–2018). Participants were divided into four groups according to quartile of blood selenium level. Liver stiffness and controlled attenuation parameter (CAP) were measured by VCTE. Multiple logistic regression models and subgroup analyses were conducted to determine the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by a variety of methods.Results A total of 3336 participants were enrolled in main analysis. In multiple logistic regression models, the higher blood selenium level (>205.32, ≤453.62 μg/L) had a significant positive association with NAFLD (β = 1.31). Moreover, high blood selenium level had significantly inversely association to advanced liver fibrosis (β = 0.61). In subgroup analysis, the main inversely correlation between blood selenium and advanced liver fibrosis was found in males with high blood selenium level. Despite dietary selenium intake being adjusted or in different subgroups, the associations between blood selenium level and NAFLD/advanced liver fibrosis remained significant.Conclusions This study showed that blood selenium level were positively association with NAFLD among US population. Participants with lower blood selenium level showed a higher percentage of advanced liver fibrosis. Blood selenium is more likely to cause NAFLD and liver fibrosis due to imbalances in selenium homeostasis rather than dietary selenium intake.Key messagesHigh blood selenium level was association with NAFLD diagnosed by vibration controlled transient elastography.Participants with lower blood selenium level had high percentage of advanced liver fibrosis.NAFLD and liver fibrosis are caused by an imbalance of selenium homeostasis, not by dietary selenium intake. |
| first_indexed | 2024-12-10T16:18:09Z |
| format | Article |
| id | doaj.art-6eb2aab33b554958ad235e29429f251f |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-12-10T16:18:09Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-6eb2aab33b554958ad235e29429f251f2022-12-22T01:41:55ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-015412259226810.1080/07853890.2022.2110277The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018Jie Liu0Liao Tan1Zhaoya Liu2Ruizheng Shi3Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of the Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, ChinaBackground & Objective Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated the relationship between selenium and non-alcoholic fatty liver disease (NAFLD) and fibrosis, these findings were still inconclusive. Our study was aimed to explore the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by vibration controlled transient elastography (VCTE) in US adults.Methods All data were extracted from National Health and Nutrition Examination Survey database (2017–2018). Participants were divided into four groups according to quartile of blood selenium level. Liver stiffness and controlled attenuation parameter (CAP) were measured by VCTE. Multiple logistic regression models and subgroup analyses were conducted to determine the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by a variety of methods.Results A total of 3336 participants were enrolled in main analysis. In multiple logistic regression models, the higher blood selenium level (>205.32, ≤453.62 μg/L) had a significant positive association with NAFLD (β = 1.31). Moreover, high blood selenium level had significantly inversely association to advanced liver fibrosis (β = 0.61). In subgroup analysis, the main inversely correlation between blood selenium and advanced liver fibrosis was found in males with high blood selenium level. Despite dietary selenium intake being adjusted or in different subgroups, the associations between blood selenium level and NAFLD/advanced liver fibrosis remained significant.Conclusions This study showed that blood selenium level were positively association with NAFLD among US population. Participants with lower blood selenium level showed a higher percentage of advanced liver fibrosis. Blood selenium is more likely to cause NAFLD and liver fibrosis due to imbalances in selenium homeostasis rather than dietary selenium intake.Key messagesHigh blood selenium level was association with NAFLD diagnosed by vibration controlled transient elastography.Participants with lower blood selenium level had high percentage of advanced liver fibrosis.NAFLD and liver fibrosis are caused by an imbalance of selenium homeostasis, not by dietary selenium intake.https://www.tandfonline.com/doi/10.1080/07853890.2022.2110277Non-alcoholic fatty liver diseaseNAFLDblood selenium levelNational Health and Nutrition Examination SurveyNHANESadvanced liver fibrosis |
| spellingShingle | Jie Liu Liao Tan Zhaoya Liu Ruizheng Shi The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 Annals of Medicine Non-alcoholic fatty liver disease NAFLD blood selenium level National Health and Nutrition Examination Survey NHANES advanced liver fibrosis |
| title | The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 |
| title_full | The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 |
| title_fullStr | The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 |
| title_full_unstemmed | The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 |
| title_short | The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018 |
| title_sort | association between non alcoholic fatty liver disease nafld and advanced fibrosis with blood selenium level based on the nhanes 2017 2018 |
| topic | Non-alcoholic fatty liver disease NAFLD blood selenium level National Health and Nutrition Examination Survey NHANES advanced liver fibrosis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2110277 |
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