Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota
Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo inter...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02823/full |
| _version_ | 1818808739791110144 |
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| author | Jonah Bardos Jonah Bardos Desiree Fiorentino Desiree Fiorentino Ryan E. Longman Ryan E. Longman Michael Paidas |
| author_facet | Jonah Bardos Jonah Bardos Desiree Fiorentino Desiree Fiorentino Ryan E. Longman Ryan E. Longman Michael Paidas |
| author_sort | Jonah Bardos |
| collection | DOAJ |
| description | Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes. |
| first_indexed | 2024-12-18T19:46:21Z |
| format | Article |
| id | doaj.art-6eb3ac72f76c4a02a88941cd5a22ed4c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-18T19:46:21Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6eb3ac72f76c4a02a88941cd5a22ed4c2022-12-21T20:55:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-01-011010.3389/fimmu.2019.02823485172Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated MicrobiotaJonah Bardos0Jonah Bardos1Desiree Fiorentino2Desiree Fiorentino3Ryan E. Longman4Ryan E. Longman5Michael Paidas6Department of Obstetrics and Gynecology, Miller School of Medicine, University of Miami, Miami, FL, United StatesDivision of Clinical and Translational Genetics, Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, United StatesDepartment of Obstetrics and Gynecology, Miller School of Medicine, University of Miami, Miami, FL, United StatesDivision of Clinical and Translational Genetics, Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, United StatesDepartment of Obstetrics and Gynecology, Miller School of Medicine, University of Miami, Miami, FL, United StatesDivision of Clinical and Translational Genetics, Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, United StatesDepartment of Obstetrics and Gynecology, Miller School of Medicine, University of Miami, Miami, FL, United StatesUnderstanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes.https://www.frontiersin.org/article/10.3389/fimmu.2019.02823/fulluterine microbiomepregnancy failurepre-eclampsiaIUGRearly pregnancy immunologyendometrial micorbiome |
| spellingShingle | Jonah Bardos Jonah Bardos Desiree Fiorentino Desiree Fiorentino Ryan E. Longman Ryan E. Longman Michael Paidas Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota Frontiers in Immunology uterine microbiome pregnancy failure pre-eclampsia IUGR early pregnancy immunology endometrial micorbiome |
| title | Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota |
| title_full | Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota |
| title_fullStr | Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota |
| title_full_unstemmed | Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota |
| title_short | Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota |
| title_sort | immunological role of the maternal uterine microbiome in pregnancy pregnancies pathologies and alterated microbiota |
| topic | uterine microbiome pregnancy failure pre-eclampsia IUGR early pregnancy immunology endometrial micorbiome |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02823/full |
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