Immobilization of Analgetic AB-101 into Calcium Alginate Gels
A new analgetic drug AB-101 has been immobilized into Ca2+-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
al-Farabi Kazakh National University
2002-10-01
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| Series: | Eurasian Chemico-Technological Journal |
| Online Access: | http://ect-journal.kz/index.php/ectj/article/view/391 |
| _version_ | 1818154252988579840 |
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| author | R.M. Iskakov E.O. Batyrbekov B.A. Zhubanov Y.Y. Fomicheva V. K. Yu K.D. Praliev D.K. Berlin |
| author_facet | R.M. Iskakov E.O. Batyrbekov B.A. Zhubanov Y.Y. Fomicheva V. K. Yu K.D. Praliev D.K. Berlin |
| author_sort | R.M. Iskakov |
| collection | DOAJ |
| description | A new analgetic drug AB-101 has been immobilized into Ca2+-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into physiological solutions consisting of sodium ions has been examined. A discontinuous time of the Fickian diffusion of the drug depending on M/G ratio was followed by a burst release of the remaining drugs. The burst release was due to a swift disintegration of Ca2+-alginate with exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium ions in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be control by M/G ratio of Ca2+-alginate gels. The lag time increases if a content of the M units decreases. The increase of M units was led to more extensive swelling of the gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect. |
| first_indexed | 2024-12-11T14:23:34Z |
| format | Article |
| id | doaj.art-6eb3c9f10b1f4eed9f1202cbb78cc2c5 |
| institution | Directory Open Access Journal |
| issn | 1562-3920 2522-4867 |
| language | English |
| last_indexed | 2024-12-11T14:23:34Z |
| publishDate | 2002-10-01 |
| publisher | al-Farabi Kazakh National University |
| record_format | Article |
| series | Eurasian Chemico-Technological Journal |
| spelling | doaj.art-6eb3c9f10b1f4eed9f1202cbb78cc2c52022-12-22T01:02:47Zengal-Farabi Kazakh National UniversityEurasian Chemico-Technological Journal1562-39202522-48672002-10-014429329510.18321/ectj547391Immobilization of Analgetic AB-101 into Calcium Alginate GelsR.M. Iskakov0E.O. Batyrbekov1B.A. Zhubanov2Y.Y. Fomicheva3V. K. Yu4K.D. Praliev5D.K. Berlin6A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanA.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanA.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanA.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanA.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanA.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, KazakhstanOklahoma State University, 107, Physical Sciences, Stillwater, 74078, Oklahoma, USAA new analgetic drug AB-101 has been immobilized into Ca2+-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into physiological solutions consisting of sodium ions has been examined. A discontinuous time of the Fickian diffusion of the drug depending on M/G ratio was followed by a burst release of the remaining drugs. The burst release was due to a swift disintegration of Ca2+-alginate with exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium ions in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be control by M/G ratio of Ca2+-alginate gels. The lag time increases if a content of the M units decreases. The increase of M units was led to more extensive swelling of the gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect.http://ect-journal.kz/index.php/ectj/article/view/391 |
| spellingShingle | R.M. Iskakov E.O. Batyrbekov B.A. Zhubanov Y.Y. Fomicheva V. K. Yu K.D. Praliev D.K. Berlin Immobilization of Analgetic AB-101 into Calcium Alginate Gels Eurasian Chemico-Technological Journal |
| title | Immobilization of Analgetic AB-101 into Calcium Alginate Gels |
| title_full | Immobilization of Analgetic AB-101 into Calcium Alginate Gels |
| title_fullStr | Immobilization of Analgetic AB-101 into Calcium Alginate Gels |
| title_full_unstemmed | Immobilization of Analgetic AB-101 into Calcium Alginate Gels |
| title_short | Immobilization of Analgetic AB-101 into Calcium Alginate Gels |
| title_sort | immobilization of analgetic ab 101 into calcium alginate gels |
| url | http://ect-journal.kz/index.php/ectj/article/view/391 |
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