SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2016;volume=7;issue=5;spage=414;epage=417;aulast=Divya |
| _version_ | 1818345286147244032 |
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| author | B Lakshmi Divya P Narasimha Rao |
| author_facet | B Lakshmi Divya P Narasimha Rao |
| author_sort | B Lakshmi Divya |
| collection | DOAJ |
| description | SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist. Magnetic resonance imaging revealed osteitis of the distal end of the right radius. Technetium-99m-MDP Whole Body Bone Scan revealed increased metaphyseal uptake in distal radius on both sides and prominent uptake at the sacroiliac joints, vertebral end plate, left 7th costo-vertebral joint and bilateral sternoclavicular joints and manubrium sternum (resulting in “bull's head” sign, which is characteristic of SAPHO syndrome). He responded very well to a combination therapy of nonsteroid anti-inflammatory drugs, antibiotics, colchicine, and isotretinoin over a 12-week period. |
| first_indexed | 2024-12-13T16:59:57Z |
| format | Article |
| id | doaj.art-6eb50ae876874a9592dc9dd0636e0128 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-13T16:59:57Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-6eb50ae876874a9592dc9dd0636e01282022-12-21T23:37:49ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782016-01-017541441710.4103/2229-5178.190495SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeletonB Lakshmi DivyaP Narasimha RaoSAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist. Magnetic resonance imaging revealed osteitis of the distal end of the right radius. Technetium-99m-MDP Whole Body Bone Scan revealed increased metaphyseal uptake in distal radius on both sides and prominent uptake at the sacroiliac joints, vertebral end plate, left 7th costo-vertebral joint and bilateral sternoclavicular joints and manubrium sternum (resulting in “bull's head” sign, which is characteristic of SAPHO syndrome). He responded very well to a combination therapy of nonsteroid anti-inflammatory drugs, antibiotics, colchicine, and isotretinoin over a 12-week period.http://www.idoj.in/article.asp?issn=2229-5178;year=2016;volume=7;issue=5;spage=414;epage=417;aulast=DivyaAcne fulminansbull-head signosteitisSAPHO syndrome |
| spellingShingle | B Lakshmi Divya P Narasimha Rao SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton Indian Dermatology Online Journal Acne fulminans bull-head sign osteitis SAPHO syndrome |
| title | SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| title_full | SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| title_fullStr | SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| title_full_unstemmed | SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| title_short | SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| title_sort | sapho syndrome with acne fulminans and severe polyosteitis involving axial skeleton |
| topic | Acne fulminans bull-head sign osteitis SAPHO syndrome |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2016;volume=7;issue=5;spage=414;epage=417;aulast=Divya |
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