Investigation of a UPR-Related Gene Signature Identifies the Pro-Fibrotic Effects of Thrombospondin-1 by Activating CD47/ROS/Endoplasmic Reticulum Stress Pathway in Lung Fibroblasts

Investigation of a UPR-Related Gene Signature Identifies the Pro-Fibrotic Effects of Thrombospondin-1 by Activating CD47/ROS/Endoplasmic Reticulum Stress Pathway in Lung Fibroblasts

Unfolded protein response (UPR) signaling and endoplasmic reticulum (ER) stress have been linked to pulmonary fibrosis. However, the relationship between UPR status and pulmonary function and prognosis in idiopathic pulmonary fibrosis (IPF) patients remains largely unknown. Through a series of bioin...

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Bibliographic Details
Main Authors:	Jun-Hui Zhan, Juan Wei, Lin Liu, Yi-Tong Xu, Hui Ji, Chang-Nan Wang, Yu-Jian Liu, Xiao-Yan Zhu
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	Antioxidants
Subjects:	TSP-1 ER stress ROS fibroblast pulmonary fibrosis
Online Access:	https://www.mdpi.com/2076-3921/12/12/2024

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