Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction

Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction

BackgroundTransplantation of adventitial pericytes (APCs) promotes cardiac repair in murine models of myocardial infarction. The aim of present study was to confirm the benefit of APC therapy in a large animal model. Methods and ResultsWe performed a blind, randomized, placebo‐controlled APC therapy...

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Bibliographic Details
Main Authors: Valeria Vincenza Alvino, Rodrigo Fernández‐Jiménez, Iker Rodriguez‐Arabaolaza, Sadie Slater, Giuseppe Mangialardi, Elisa Avolio, Helen Spencer, Lucy Culliford, Sakinah Hassan, Lorena Sueiro Ballesteros, Andrew Herman, Ali Ayaon‐Albarrán, Carlos Galán‐Arriola, Javier Sánchez‐González, Helena Hennessey, Catherine Delmege, Raimondo Ascione, Costanza Emanueli, Gianni Davide Angelini, Borja Ibanez, Paolo Madeddu
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis
cell therapy
large animal models
myocardial infarction
pericytes
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006727

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