Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i>
South Africa’s highly diverse marine biota includes several endemic marine red algae of the <i>Laurencia</i> genus. Cryptic species and morphological variability make the taxonomy of <i>Laurencia</i> plant challenging, and a record of the secondary metabolites isolated from S...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/5/2063 |
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| author | Jameel Fakee John J. Bolton Marilize Le Roes-Hill Kim A. Durrell Edith Antunes Denzil R. Beukes |
| author_facet | Jameel Fakee John J. Bolton Marilize Le Roes-Hill Kim A. Durrell Edith Antunes Denzil R. Beukes |
| author_sort | Jameel Fakee |
| collection | DOAJ |
| description | South Africa’s highly diverse marine biota includes several endemic marine red algae of the <i>Laurencia</i> genus. Cryptic species and morphological variability make the taxonomy of <i>Laurencia</i> plant challenging, and a record of the secondary metabolites isolated from South African <i>Laurencia</i> spp. can be used to assess their chemotaxonomic significance. In addition, the rapid development of resistance against antibiotics, coupled with the inherent ability of seaweeds to resist pathogenic infection, supported this first phycochemical investigation of <i>Laurencia corymbosa</i> J. Agardh. A new tricyclic keto-cuparane (<b>7</b>) and two new cuparanes (<b>4, 5</b>) were obtained alongside known acetogenins, halo-chamigranes, and additional cuparanes. These compounds were screened against <i>Acinetobacter baumannii</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i>, with <b>4</b> exhibiting excellent activity against the Gram-negative <i>A. baumanii</i> (minimum inhibitory concentration (MIC) 1 μg/mL) strain. |
| first_indexed | 2024-03-11T07:17:40Z |
| format | Article |
| id | doaj.art-6eb6ceb6922c427ab847c2154c8745f3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:17:40Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6eb6ceb6922c427ab847c2154c8745f32023-11-17T08:11:29ZengMDPI AGMolecules1420-30492023-02-01285206310.3390/molecules28052063Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i>Jameel Fakee0John J. Bolton1Marilize Le Roes-Hill2Kim A. Durrell3Edith Antunes4Denzil R. Beukes5Faculty of Pharmacy, Rhodes University, Makhanda 6140, South AfricaDepartment of Biological Sciences, University of Cape Town, Rondebosch 7701, South AfricaApplied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Bellville 7535, South AfricaApplied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Bellville 7535, South AfricaDepartment of Chemistry, University of the Western Cape, Bellville 7535, South AfricaSchool of Pharmacy, University of the Western Cape, Bellville 7535, South AfricaSouth Africa’s highly diverse marine biota includes several endemic marine red algae of the <i>Laurencia</i> genus. Cryptic species and morphological variability make the taxonomy of <i>Laurencia</i> plant challenging, and a record of the secondary metabolites isolated from South African <i>Laurencia</i> spp. can be used to assess their chemotaxonomic significance. In addition, the rapid development of resistance against antibiotics, coupled with the inherent ability of seaweeds to resist pathogenic infection, supported this first phycochemical investigation of <i>Laurencia corymbosa</i> J. Agardh. A new tricyclic keto-cuparane (<b>7</b>) and two new cuparanes (<b>4, 5</b>) were obtained alongside known acetogenins, halo-chamigranes, and additional cuparanes. These compounds were screened against <i>Acinetobacter baumannii</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i>, with <b>4</b> exhibiting excellent activity against the Gram-negative <i>A. baumanii</i> (minimum inhibitory concentration (MIC) 1 μg/mL) strain.https://www.mdpi.com/1420-3049/28/5/2063<i>Laurencia corymbosa</i>cuparaneschamigranesantimicrobial activity |
| spellingShingle | Jameel Fakee John J. Bolton Marilize Le Roes-Hill Kim A. Durrell Edith Antunes Denzil R. Beukes Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> Molecules <i>Laurencia corymbosa</i> cuparanes chamigranes antimicrobial activity |
| title | Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> |
| title_full | Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> |
| title_fullStr | Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> |
| title_full_unstemmed | Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> |
| title_short | Antimicrobial Activity of the Secondary Metabolites Isolated from a South African Red Seaweed, <i>Laurencia corymbosa</i> |
| title_sort | antimicrobial activity of the secondary metabolites isolated from a south african red seaweed i laurencia corymbosa i |
| topic | <i>Laurencia corymbosa</i> cuparanes chamigranes antimicrobial activity |
| url | https://www.mdpi.com/1420-3049/28/5/2063 |
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