Combining the best of both worlds: radical-based divergent total synthesis
A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2023-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.19.1 |
| _version_ | 1811170119274987520 |
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| author | Kyriaki Gennaiou Antonios Kelesidis Maria Kourgiantaki Alexandros L. Zografos |
| author_facet | Kyriaki Gennaiou Antonios Kelesidis Maria Kourgiantaki Alexandros L. Zografos |
| author_sort | Kyriaki Gennaiou |
| collection | DOAJ |
| description | A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds. |
| first_indexed | 2024-04-10T16:53:04Z |
| format | Article |
| id | doaj.art-6eb8b5d282d743b8800d7c1f45e8514d |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-04-10T16:53:04Z |
| publishDate | 2023-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-6eb8b5d282d743b8800d7c1f45e8514d2023-02-07T10:59:15ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972023-01-0119112610.3762/bjoc.19.11860-5397-19-1Combining the best of both worlds: radical-based divergent total synthesisKyriaki Gennaiou0Antonios Kelesidis1Maria Kourgiantaki2Alexandros L. Zografos3Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Organic Chemistry, Thessaloniki, 54124, Greece Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Organic Chemistry, Thessaloniki, 54124, Greece Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Organic Chemistry, Thessaloniki, 54124, Greece Aristotle University of Thessaloniki, Department of Chemistry, Laboratory of Organic Chemistry, Thessaloniki, 54124, Greece A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds.https://doi.org/10.3762/bjoc.19.1biomimetic synthesiscascadescommon scaffoldhydrogen atom transferphotoredox catalysis |
| spellingShingle | Kyriaki Gennaiou Antonios Kelesidis Maria Kourgiantaki Alexandros L. Zografos Combining the best of both worlds: radical-based divergent total synthesis Beilstein Journal of Organic Chemistry biomimetic synthesis cascades common scaffold hydrogen atom transfer photoredox catalysis |
| title | Combining the best of both worlds: radical-based divergent total synthesis |
| title_full | Combining the best of both worlds: radical-based divergent total synthesis |
| title_fullStr | Combining the best of both worlds: radical-based divergent total synthesis |
| title_full_unstemmed | Combining the best of both worlds: radical-based divergent total synthesis |
| title_short | Combining the best of both worlds: radical-based divergent total synthesis |
| title_sort | combining the best of both worlds radical based divergent total synthesis |
| topic | biomimetic synthesis cascades common scaffold hydrogen atom transfer photoredox catalysis |
| url | https://doi.org/10.3762/bjoc.19.1 |
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