Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes
Abstract Background The triglyceride glucose (TyG) index has been considered a new biomarker for the diagnosis of angiocardiopathy and insulin resistance. However, the association of the TyG index with subclinical left ventricular (LV) systolic dysfunction still lacks comprehensive exploration. This...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01796-1 |
| _version_ | 1797863678512463872 |
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| author | Yanyan Chen Jianfang Fu Yi Wang Ying Zhang Min Shi Cheng Wang Mengying Li Li Wang Xiangyang Liu Shengjun Ta Liwen Liu Zeping Li Xiaomiao Li Jie Zhou |
| author_facet | Yanyan Chen Jianfang Fu Yi Wang Ying Zhang Min Shi Cheng Wang Mengying Li Li Wang Xiangyang Liu Shengjun Ta Liwen Liu Zeping Li Xiaomiao Li Jie Zhou |
| author_sort | Yanyan Chen |
| collection | DOAJ |
| description | Abstract Background The triglyceride glucose (TyG) index has been considered a new biomarker for the diagnosis of angiocardiopathy and insulin resistance. However, the association of the TyG index with subclinical left ventricular (LV) systolic dysfunction still lacks comprehensive exploration. This study was carried out to examine this relationship in patients with type 2 diabetes mellitus (T2DM). Methods A total of 150 T2DM patients with preserved LV ejection fraction (LVEF ≥ 50%) from June 2021 to December 2021 were included in this study. The subclinical LV function was evaluated through global longitudinal strain (GLS), with the predefined GLS < 18% as the cutoff for subclinical LV systolic dysfunction. The TyG index calculation was obtained according to ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2), which was then stratified into quartiles (TyG index—Q). Results Analyses of clinical characteristics in the four TyG indexes-Q (Q1 (TyG index ≤ 8.89) n = 38, Q2 (8.89 < TyG index ≤ 9.44) n = 37, Q3 (9.44 < TyG index ≤ 9.83) n = 38, and Q4 (TyG index > 9.83) n = 37) were conducted. A negative correlation of the TyG index with GLS (r = -0.307, P < 0.001) was revealed according to correlation analysis. After gender and age were adjusted in multimodel logistic regression analysis, the higher TyG index (OR 6.86; 95% CI 2.44 to 19.30; P < 0.001, Q4 vs Q1) showed a significant association with GLS < 18%, which was still maintained after further adjustment for related clinical confounding factors (OR 5.23, 95% CI 1.12 to 24.51, p = 0.036, Q4 vs Q1). Receiver operator characteristic analysis indicated a diagnostic capacity of the TyG index for GLS < 18% (area under curve: 0.678; P < 0.001). Conclusions A higher TyG index had a significant association with subclinical LV systolic dysfunction in T2DM patients with preserved ejection fraction, and the TyG index may have the potential to exert predictive value for myocardial damage. |
| first_indexed | 2024-04-09T22:40:31Z |
| format | Article |
| id | doaj.art-6eb99286491b4237ab9d752729217dce |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-09T22:40:31Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-6eb99286491b4237ab9d752729217dce2023-03-22T12:14:48ZengBMCLipids in Health and Disease1476-511X2023-03-012211910.1186/s12944-023-01796-1Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetesYanyan Chen0Jianfang Fu1Yi Wang2Ying Zhang3Min Shi4Cheng Wang5Mengying Li6Li Wang7Xiangyang Liu8Shengjun Ta9Liwen Liu10Zeping Li11Xiaomiao Li12Jie Zhou13Department of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Ultrasound, Xijing Hospital, Air Force Medical UniversityDepartment of Ultrasound, Xijing Hospital, Air Force Medical UniversityNanchang University Queen Mary SchoolDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityDepartment of Endocrinology, Xijing Hospital, Air Force Medical UniversityAbstract Background The triglyceride glucose (TyG) index has been considered a new biomarker for the diagnosis of angiocardiopathy and insulin resistance. However, the association of the TyG index with subclinical left ventricular (LV) systolic dysfunction still lacks comprehensive exploration. This study was carried out to examine this relationship in patients with type 2 diabetes mellitus (T2DM). Methods A total of 150 T2DM patients with preserved LV ejection fraction (LVEF ≥ 50%) from June 2021 to December 2021 were included in this study. The subclinical LV function was evaluated through global longitudinal strain (GLS), with the predefined GLS < 18% as the cutoff for subclinical LV systolic dysfunction. The TyG index calculation was obtained according to ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2), which was then stratified into quartiles (TyG index—Q). Results Analyses of clinical characteristics in the four TyG indexes-Q (Q1 (TyG index ≤ 8.89) n = 38, Q2 (8.89 < TyG index ≤ 9.44) n = 37, Q3 (9.44 < TyG index ≤ 9.83) n = 38, and Q4 (TyG index > 9.83) n = 37) were conducted. A negative correlation of the TyG index with GLS (r = -0.307, P < 0.001) was revealed according to correlation analysis. After gender and age were adjusted in multimodel logistic regression analysis, the higher TyG index (OR 6.86; 95% CI 2.44 to 19.30; P < 0.001, Q4 vs Q1) showed a significant association with GLS < 18%, which was still maintained after further adjustment for related clinical confounding factors (OR 5.23, 95% CI 1.12 to 24.51, p = 0.036, Q4 vs Q1). Receiver operator characteristic analysis indicated a diagnostic capacity of the TyG index for GLS < 18% (area under curve: 0.678; P < 0.001). Conclusions A higher TyG index had a significant association with subclinical LV systolic dysfunction in T2DM patients with preserved ejection fraction, and the TyG index may have the potential to exert predictive value for myocardial damage.https://doi.org/10.1186/s12944-023-01796-1Type 2 diabetes mellitusTriglyceride glucose indexGlobal longitudinal strainLeft ventricular systolic functionInsulin resistance |
| spellingShingle | Yanyan Chen Jianfang Fu Yi Wang Ying Zhang Min Shi Cheng Wang Mengying Li Li Wang Xiangyang Liu Shengjun Ta Liwen Liu Zeping Li Xiaomiao Li Jie Zhou Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes Lipids in Health and Disease Type 2 diabetes mellitus Triglyceride glucose index Global longitudinal strain Left ventricular systolic function Insulin resistance |
| title | Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| title_full | Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| title_fullStr | Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| title_full_unstemmed | Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| title_short | Association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| title_sort | association between triglyceride glucose index and subclinical left ventricular systolic dysfunction in patients with type 2 diabetes |
| topic | Type 2 diabetes mellitus Triglyceride glucose index Global longitudinal strain Left ventricular systolic function Insulin resistance |
| url | https://doi.org/10.1186/s12944-023-01796-1 |
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