Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
BackgroundFrailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1166365/full |
| _version_ | 1797814278365904896 |
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| author | Rosa Estela García-Chanes José Alberto Avila-Funes José Alberto Avila-Funes Miguel Germán Borda Mario Ulises Pérez-Zepeda Mario Ulises Pérez-Zepeda Luis Miguel Gutiérrez-Robledo Luis Miguel Gutiérrez-Robledo |
| author_facet | Rosa Estela García-Chanes José Alberto Avila-Funes José Alberto Avila-Funes Miguel Germán Borda Mario Ulises Pérez-Zepeda Mario Ulises Pérez-Zepeda Luis Miguel Gutiérrez-Robledo Luis Miguel Gutiérrez-Robledo |
| author_sort | Rosa Estela García-Chanes |
| collection | DOAJ |
| description | BackgroundFrailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries.MethodsWe analyzed the baseline the Study on Global Ageing and Adult Health (SAGE), that includes six countries (Ghana, South Africa, Mexico, China, Russia, and India). A cross-section analysis was used to assess how Frailty was related with the Clinical Frailty Scale decision tree, while cognitive decline was evaluated using standardized scores of tests used in SAGE.ResultsA total of 30,674 participants aged 50 years or older were included. There was an association between frailty levels and cognitive performance. For example, women had an inverse relationship between frailty levels and cognitive scores, even when comparing robust category with frailty level 2 (RRR = 0.85; p = 0.41), although the relative risks decrease significantly at level 3 (RRR = 0.66; p = 0.03). When controlling for age, the relative risks between frailty levels 4 to 7 significantly decreased as cognitive performance increased (RRR = 0.46, RRR = 0.52, RRR = 0.44, RRR = 0.32; p < 0.001).ConclusionOur results show an association between frailty levels measured in a novel way, and cognitive decline across different cultural settings. |
| first_indexed | 2024-03-13T08:05:15Z |
| format | Article |
| id | doaj.art-6ebb55ddc9614886ae444b03ff9a0d45 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T08:05:15Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-6ebb55ddc9614886ae444b03ff9a0d452023-06-01T05:24:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11663651166365Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult healthRosa Estela García-Chanes0José Alberto Avila-Funes1José Alberto Avila-Funes2Miguel Germán Borda3Mario Ulises Pérez-Zepeda4Mario Ulises Pérez-Zepeda5Luis Miguel Gutiérrez-Robledo6Luis Miguel Gutiérrez-Robledo7Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoBordeaux Population Health Research Center, INSERM-University of Bordeaux, UMR 1219, Bordeaux, FranceCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, NorwayDirección de Investigación, Instituto Nacional de Geriatría, Mexico City, MexicoCentro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Huixquilucan de Degollado, MexicoDirección de Investigación, Instituto Nacional de Geriatría, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoBackgroundFrailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries.MethodsWe analyzed the baseline the Study on Global Ageing and Adult Health (SAGE), that includes six countries (Ghana, South Africa, Mexico, China, Russia, and India). A cross-section analysis was used to assess how Frailty was related with the Clinical Frailty Scale decision tree, while cognitive decline was evaluated using standardized scores of tests used in SAGE.ResultsA total of 30,674 participants aged 50 years or older were included. There was an association between frailty levels and cognitive performance. For example, women had an inverse relationship between frailty levels and cognitive scores, even when comparing robust category with frailty level 2 (RRR = 0.85; p = 0.41), although the relative risks decrease significantly at level 3 (RRR = 0.66; p = 0.03). When controlling for age, the relative risks between frailty levels 4 to 7 significantly decreased as cognitive performance increased (RRR = 0.46, RRR = 0.52, RRR = 0.44, RRR = 0.32; p < 0.001).ConclusionOur results show an association between frailty levels measured in a novel way, and cognitive decline across different cultural settings.https://www.frontiersin.org/articles/10.3389/fmed.2023.1166365/fullfrailtygeriatric epidemiologycognitive impairmentSAGEmulti-country study |
| spellingShingle | Rosa Estela García-Chanes José Alberto Avila-Funes José Alberto Avila-Funes Miguel Germán Borda Mario Ulises Pérez-Zepeda Mario Ulises Pérez-Zepeda Luis Miguel Gutiérrez-Robledo Luis Miguel Gutiérrez-Robledo Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health Frontiers in Medicine frailty geriatric epidemiology cognitive impairment SAGE multi-country study |
| title | Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health |
| title_full | Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health |
| title_fullStr | Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health |
| title_full_unstemmed | Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health |
| title_short | Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health |
| title_sort | higher frailty levels are associated with lower cognitive test scores in a multi country study evidence from the study on global ageing and adult health |
| topic | frailty geriatric epidemiology cognitive impairment SAGE multi-country study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1166365/full |
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