Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have beco...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4970 |
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| author | Tapan Behl Rashita Makkar Aayush Sehgal Neelam Sharma Sukhbir Singh Mohammed Albratty Asim Najmi Abdulkarim M. Meraya Simona Gabriela Bungau |
| author_facet | Tapan Behl Rashita Makkar Aayush Sehgal Neelam Sharma Sukhbir Singh Mohammed Albratty Asim Najmi Abdulkarim M. Meraya Simona Gabriela Bungau |
| author_sort | Tapan Behl |
| collection | DOAJ |
| description | The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have become exceedingly prominent and pose a significant burden mentally, socially and economically on both the individual and their family. These disorders express several symptoms, such as tremors, dystonia, loss of cognitive functions, impairment of motor activity leading to immobility, loss of memory and many more which worsen with time. The treatment employed in management of these debilitating neurodegenerative disorders, such as Parkinson’s disease (which mainly involves the loss of dopaminergic neurons in the nigrostriatal region), Alzheimer’s disease (which arises due to accumulation of Tau proteins causing diffusive atrophy in the brain), Huntington’s disease (which involves damage of striatal and spinal neurons, etc.), have several adverse effects, leading to exploration of several lead targets and molecules existing in herbal drugs. The current review highlights the mechanistic role of natural products in the treatment of several neurodegenerative and cerebrovascular diseases such as Parkinson’s disease, Alzheimer’s disease, ischemic stroke and depression. |
| first_indexed | 2024-03-09T12:20:52Z |
| format | Article |
| id | doaj.art-6ebdeab77743404798eaa2e9a7d54da9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:20:52Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6ebdeab77743404798eaa2e9a7d54da92023-11-30T22:41:18ZengMDPI AGMolecules1420-30492022-08-012715497010.3390/molecules27154970Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular DisordersTapan Behl0Rashita Makkar1Aayush Sehgal2Neelam Sharma3Sukhbir Singh4Mohammed Albratty5Asim Najmi6Abdulkarim M. Meraya7Simona Gabriela Bungau8Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaDepartment of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala 133207, Haryana, IndiaDepartment of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala 133207, Haryana, IndiaDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaPharmacy Practice Research Unit, Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45124, Saudi ArabiaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaThe longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have become exceedingly prominent and pose a significant burden mentally, socially and economically on both the individual and their family. These disorders express several symptoms, such as tremors, dystonia, loss of cognitive functions, impairment of motor activity leading to immobility, loss of memory and many more which worsen with time. The treatment employed in management of these debilitating neurodegenerative disorders, such as Parkinson’s disease (which mainly involves the loss of dopaminergic neurons in the nigrostriatal region), Alzheimer’s disease (which arises due to accumulation of Tau proteins causing diffusive atrophy in the brain), Huntington’s disease (which involves damage of striatal and spinal neurons, etc.), have several adverse effects, leading to exploration of several lead targets and molecules existing in herbal drugs. The current review highlights the mechanistic role of natural products in the treatment of several neurodegenerative and cerebrovascular diseases such as Parkinson’s disease, Alzheimer’s disease, ischemic stroke and depression.https://www.mdpi.com/1420-3049/27/15/4970neurodegenerative disordersnatural productsbioactive compoundsParkinson’s diseaseAlzheimer’s diseaseHuntington’s disease |
| spellingShingle | Tapan Behl Rashita Makkar Aayush Sehgal Neelam Sharma Sukhbir Singh Mohammed Albratty Asim Najmi Abdulkarim M. Meraya Simona Gabriela Bungau Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders Molecules neurodegenerative disorders natural products bioactive compounds Parkinson’s disease Alzheimer’s disease Huntington’s disease |
| title | Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders |
| title_full | Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders |
| title_fullStr | Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders |
| title_full_unstemmed | Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders |
| title_short | Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders |
| title_sort | insights into the explicit protective activity of herbals in management of neurodegenerative and cerebrovascular disorders |
| topic | neurodegenerative disorders natural products bioactive compounds Parkinson’s disease Alzheimer’s disease Huntington’s disease |
| url | https://www.mdpi.com/1420-3049/27/15/4970 |
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