Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases
Aging is the most important factor contributing to cardiovascular diseases (CVDs), and the incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is the leading cause of death in the global population. In-depth analysis of the mechanisms and interventions of cardio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1202378/full |
| _version_ | 1797793802083106816 |
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| author | Jun Guo Kai Li Yajun Lin Yinghua Liu Yinghua Liu |
| author_facet | Jun Guo Kai Li Yajun Lin Yinghua Liu Yinghua Liu |
| author_sort | Jun Guo |
| collection | DOAJ |
| description | Aging is the most important factor contributing to cardiovascular diseases (CVDs), and the incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is the leading cause of death in the global population. In-depth analysis of the mechanisms and interventions of cardiovascular aging and related diseases is an important basis for achieving healthy aging. Tea polyphenols (TPs) are the general term for the polyhydroxy compounds contained in tea leaves, whose main components are catechins, flavonoids, flavonols, anthocyanins, phenolic acids, condensed phenolic acids and polymeric phenols. Among them, catechins are the main components of TPs. In this article, we provide a detailed review of the classification and composition of teas, as well as an overview of the causes of aging-related CVDs. Then, we focus on ten aspects of the effects of TPs, including anti-hypertension, lipid-lowering effects, anti-oxidation, anti-inflammation, anti-proliferation, anti-angiogenesis, anti-atherosclerosis, recovery of endothelial function, anti-thrombosis, myocardial protective effect, to improve CVDs and the detailed molecular mechanisms. |
| first_indexed | 2024-03-13T02:53:34Z |
| format | Article |
| id | doaj.art-6ec393159dee49b99e61147c69030ce3 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T02:53:34Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-6ec393159dee49b99e61147c69030ce32023-06-28T08:51:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.12023781202378Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseasesJun Guo0Kai Li1Yajun Lin2Yinghua Liu3Yinghua Liu4The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, ChinaGeneral Surgery Department, The First People’s Hospital of Tai’an City, Tai’an, ChinaThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, ChinaDepartment of Nutrition, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaAging is the most important factor contributing to cardiovascular diseases (CVDs), and the incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is the leading cause of death in the global population. In-depth analysis of the mechanisms and interventions of cardiovascular aging and related diseases is an important basis for achieving healthy aging. Tea polyphenols (TPs) are the general term for the polyhydroxy compounds contained in tea leaves, whose main components are catechins, flavonoids, flavonols, anthocyanins, phenolic acids, condensed phenolic acids and polymeric phenols. Among them, catechins are the main components of TPs. In this article, we provide a detailed review of the classification and composition of teas, as well as an overview of the causes of aging-related CVDs. Then, we focus on ten aspects of the effects of TPs, including anti-hypertension, lipid-lowering effects, anti-oxidation, anti-inflammation, anti-proliferation, anti-angiogenesis, anti-atherosclerosis, recovery of endothelial function, anti-thrombosis, myocardial protective effect, to improve CVDs and the detailed molecular mechanisms.https://www.frontiersin.org/articles/10.3389/fnut.2023.1202378/fullagingcardiovascular diseasestea polyphenolspreventiontreatment |
| spellingShingle | Jun Guo Kai Li Yajun Lin Yinghua Liu Yinghua Liu Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases Frontiers in Nutrition aging cardiovascular diseases tea polyphenols prevention treatment |
| title | Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| title_full | Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| title_fullStr | Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| title_full_unstemmed | Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| title_short | Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| title_sort | protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases |
| topic | aging cardiovascular diseases tea polyphenols prevention treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1202378/full |
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