Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine
Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1080238/full |
| _version_ | 1827931509910142976 |
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| author | Edgar Alonso Melgoza-González Lorena Bustamante-Córdova Jesús Hernández |
| author_facet | Edgar Alonso Melgoza-González Lorena Bustamante-Córdova Jesús Hernández |
| author_sort | Edgar Alonso Melgoza-González |
| collection | DOAJ |
| description | Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direct influence on the elicited response that will ensue after antigen uptake. Different approaches using antibodies, natural or synthetic ligands, fused proteins, and DNA vaccines have been explored in various veterinary species, with pigs, cattle, sheep, and poultry as the most frequent models. Antigen-presenting cells can be targeted using a generic approach, such as broadly expressed receptors such as MHC-II, CD80/86, CD40, CD83, etc., or focused on specific cell populations such as dendritic cells or macrophages (Langerin, DC-SIGN, XCR1, DC peptides, sialoadhesin, mannose receptors, etc.) with contrasting results. Interestingly, DC peptides show high specificity to DCs, boosting activation, stimulating cellular and humoral responses, and a higher rate of clinical protection. Likewise, MHC-II targeting shows consistent results in enhancing both immune responses; an example of this strategy of targeting is the approved vaccine against the bovine viral diarrhea virus in South America. This significant milestone opens the door to continuing efforts toward antigen-targeting vaccines to benefit animal health. This review discusses the recent advances in antigen targeting to antigen-presenting cells in veterinary medicine, with a special interest in pigs, sheep, cattle, poultry, and dogs. |
| first_indexed | 2024-03-13T06:53:46Z |
| format | Article |
| id | doaj.art-6ec40a03fbc54d03a04a18a9a4dc5bbc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T06:53:46Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6ec40a03fbc54d03a04a18a9a4dc5bbc2023-06-07T12:36:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.10802381080238Recent advances in antigen targeting to antigen-presenting cells in veterinary medicineEdgar Alonso Melgoza-GonzálezLorena Bustamante-CórdovaJesús HernándezAdvances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direct influence on the elicited response that will ensue after antigen uptake. Different approaches using antibodies, natural or synthetic ligands, fused proteins, and DNA vaccines have been explored in various veterinary species, with pigs, cattle, sheep, and poultry as the most frequent models. Antigen-presenting cells can be targeted using a generic approach, such as broadly expressed receptors such as MHC-II, CD80/86, CD40, CD83, etc., or focused on specific cell populations such as dendritic cells or macrophages (Langerin, DC-SIGN, XCR1, DC peptides, sialoadhesin, mannose receptors, etc.) with contrasting results. Interestingly, DC peptides show high specificity to DCs, boosting activation, stimulating cellular and humoral responses, and a higher rate of clinical protection. Likewise, MHC-II targeting shows consistent results in enhancing both immune responses; an example of this strategy of targeting is the approved vaccine against the bovine viral diarrhea virus in South America. This significant milestone opens the door to continuing efforts toward antigen-targeting vaccines to benefit animal health. This review discusses the recent advances in antigen targeting to antigen-presenting cells in veterinary medicine, with a special interest in pigs, sheep, cattle, poultry, and dogs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1080238/fullantigen targetantigen presenting cellreceptorsveterinaryvaccines |
| spellingShingle | Edgar Alonso Melgoza-González Lorena Bustamante-Córdova Jesús Hernández Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine Frontiers in Immunology antigen target antigen presenting cell receptors veterinary vaccines |
| title | Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine |
| title_full | Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine |
| title_fullStr | Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine |
| title_full_unstemmed | Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine |
| title_short | Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine |
| title_sort | recent advances in antigen targeting to antigen presenting cells in veterinary medicine |
| topic | antigen target antigen presenting cell receptors veterinary vaccines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1080238/full |
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