The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease
Background: (1) Sleep disorders are prevalent in coronary artery disease (CAD) patients and predict cardiac events and prognosis. While increased oxidative stress (OS) has been associated with sleep disorders, less is known about its relationship with sleep quality. Similarly, little is known of how...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/8/1070 |
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| author | Vivian Feng Shankar Tumati Ruoding Wang Kritleen K. Bawa Damien Gallagher Nathan Herrmann Susan Marzolini Paul Oh Ana Andreazza Krista L. Lanctôt |
| author_facet | Vivian Feng Shankar Tumati Ruoding Wang Kritleen K. Bawa Damien Gallagher Nathan Herrmann Susan Marzolini Paul Oh Ana Andreazza Krista L. Lanctôt |
| author_sort | Vivian Feng |
| collection | DOAJ |
| description | Background: (1) Sleep disorders are prevalent in coronary artery disease (CAD) patients and predict cardiac events and prognosis. While increased oxidative stress (OS) has been associated with sleep disorders, less is known about its relationship with sleep quality. Similarly, little is known of how this relationship might change with exercise, which can improve sleep quality. Factors of sleep quality, such as sleep duration and disturbances, are also important as they predict cardiovascular diseases better than a global score alone. This study investigated whether OS was associated with self-rated sleep quality and its factors before and after completing a 24-week exercise intervention. (2) Methods: CAD patients undergoing an exercise program were recruited. OS was measured at baseline by the concentrations of early- (lipid hydroperoxides, LPH) and late-stage (8-isoprostane, 8-ISO) lipid peroxidation products and their ratio. Sleep quality was measured by the self-reported Pittsburgh Sleep Quality Index (PSQI) instrument at baseline and termination. Three sleep factors—perceived sleep quality, sleep efficiency, and daily disturbances—were derived from the PSQI. (3) Results: Among CAD patients (<i>n</i> = 113, 85.0% male, age = 63.7 ± 6.4 years, global PSQI = 5.8 ± 4.0), those with poor sleep (PSQI ≥ 5) had higher baseline 8-ISO levels (F(1, 111) = 6.212, <i>p</i> = 0.014, η<sub>p</sub><sup>2</sup> = 0.053) compared to those with normal sleep. Concentrations of LPH (F(1, 105) = 0.569, <i>p</i> = 0.453, η<sub>p</sub><sup>2</sup> = 0.005) and 8-ISO/LPH ratios (F(1, 105) = 2.173, <i>p</i> = 0.143, η<sub>p</sub><sup>2</sup> = 0.020) did not differ between those with poor sleep and normal sleep. Among factors, perceived sleep quality was associated with 8-ISO and 8-ISO/LPH, and daily disturbances were associated with 8-ISO. (4) Conclusions: A marker of late-stage lipid peroxidation is elevated in CAD patients with poor sleep and associated with daily disturbances, but not with other factors or with sleep quality and its factors after exercise intervention. |
| first_indexed | 2024-03-09T09:59:30Z |
| format | Article |
| id | doaj.art-6ec471677f1b48ce808ebfafb92cac7e |
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| language | English |
| last_indexed | 2024-03-09T09:59:30Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-6ec471677f1b48ce808ebfafb92cac7e2023-12-01T23:31:16ZengMDPI AGBrain Sciences2076-34252022-08-01128107010.3390/brainsci12081070The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery DiseaseVivian Feng0Shankar Tumati1Ruoding Wang2Kritleen K. Bawa3Damien Gallagher4Nathan Herrmann5Susan Marzolini6Paul Oh7Ana Andreazza8Krista L. Lanctôt9Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaKITE Toronto Rehabilitation Institute, University Health Network, East York, ON M5G 2A2, CanadaKITE Toronto Rehabilitation Institute, University Health Network, East York, ON M5G 2A2, CanadaDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, 1 King’s College Cir, Toronto, ON M5S 1A8, CanadaNeuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, CanadaBackground: (1) Sleep disorders are prevalent in coronary artery disease (CAD) patients and predict cardiac events and prognosis. While increased oxidative stress (OS) has been associated with sleep disorders, less is known about its relationship with sleep quality. Similarly, little is known of how this relationship might change with exercise, which can improve sleep quality. Factors of sleep quality, such as sleep duration and disturbances, are also important as they predict cardiovascular diseases better than a global score alone. This study investigated whether OS was associated with self-rated sleep quality and its factors before and after completing a 24-week exercise intervention. (2) Methods: CAD patients undergoing an exercise program were recruited. OS was measured at baseline by the concentrations of early- (lipid hydroperoxides, LPH) and late-stage (8-isoprostane, 8-ISO) lipid peroxidation products and their ratio. Sleep quality was measured by the self-reported Pittsburgh Sleep Quality Index (PSQI) instrument at baseline and termination. Three sleep factors—perceived sleep quality, sleep efficiency, and daily disturbances—were derived from the PSQI. (3) Results: Among CAD patients (<i>n</i> = 113, 85.0% male, age = 63.7 ± 6.4 years, global PSQI = 5.8 ± 4.0), those with poor sleep (PSQI ≥ 5) had higher baseline 8-ISO levels (F(1, 111) = 6.212, <i>p</i> = 0.014, η<sub>p</sub><sup>2</sup> = 0.053) compared to those with normal sleep. Concentrations of LPH (F(1, 105) = 0.569, <i>p</i> = 0.453, η<sub>p</sub><sup>2</sup> = 0.005) and 8-ISO/LPH ratios (F(1, 105) = 2.173, <i>p</i> = 0.143, η<sub>p</sub><sup>2</sup> = 0.020) did not differ between those with poor sleep and normal sleep. Among factors, perceived sleep quality was associated with 8-ISO and 8-ISO/LPH, and daily disturbances were associated with 8-ISO. (4) Conclusions: A marker of late-stage lipid peroxidation is elevated in CAD patients with poor sleep and associated with daily disturbances, but not with other factors or with sleep quality and its factors after exercise intervention.https://www.mdpi.com/2076-3425/12/8/1070sleep qualityoxidative stresscoronary artery disease |
| spellingShingle | Vivian Feng Shankar Tumati Ruoding Wang Kritleen K. Bawa Damien Gallagher Nathan Herrmann Susan Marzolini Paul Oh Ana Andreazza Krista L. Lanctôt The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease Brain Sciences sleep quality oxidative stress coronary artery disease |
| title | The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease |
| title_full | The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease |
| title_fullStr | The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease |
| title_full_unstemmed | The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease |
| title_short | The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease |
| title_sort | relationship between oxidative stress and subjective sleep quality in people with coronary artery disease |
| topic | sleep quality oxidative stress coronary artery disease |
| url | https://www.mdpi.com/2076-3425/12/8/1070 |
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