Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran
This study was aimed to determine prevalence of Vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2012-07-01
|
| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3935 |
| _version_ | 1819032209008361472 |
|---|---|
| author | Bahram Mohammadi Mehri Najafi Fateme Farahmand Farzaneh Motamed Mahsa Ghajarzadeh Jamshid Mohammadi Mohammad Eshagh Roze |
| author_facet | Bahram Mohammadi Mehri Najafi Fateme Farahmand Farzaneh Motamed Mahsa Ghajarzadeh Jamshid Mohammadi Mohammad Eshagh Roze |
| author_sort | Bahram Mohammadi |
| collection | DOAJ |
| description | This study was aimed to determine prevalence of Vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March 2011 were enrolled in a cross-sectional study. Laboratory analysis including calcium, phosphate, albumin, total and direct bilirubin, aminotransferases, alkalinephosphatase (ALP), prothrombin time (PT), parathyroid hormone (PTH), total protein determined by routine laboratory techniques. Mean age of participants was 299.1 ± 676.8 days (range 2-3600 days) whereas twenty one were female (43.8%) and 27 (56.3%) were male. Twenty two (45.8%) had evidences of rickets in X-ray evaluation. Three children with rickets and two with normal X-ray had Vitamin D deficiency while ten in rickets group and 16 in normal group had Vitamin D insufficiency. The main underlying diseases were anatomical biliary atresia in cases with rickets and idiopathic in other group. Rickets and Vitamin D deficiency should be considered in chronic cholestatic children. |
| first_indexed | 2024-12-21T06:58:18Z |
| format | Article |
| id | doaj.art-6ec4b5c2d48e46b18bace5ed2d44b1ec |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T06:58:18Z |
| publishDate | 2012-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-6ec4b5c2d48e46b18bace5ed2d44b1ec2022-12-21T19:12:16ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-07-01507Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in IranBahram Mohammadi0Mehri Najafi1Fateme Farahmand2Farzaneh Motamed3Mahsa Ghajarzadeh4Jamshid Mohammadi5Mohammad Eshagh Roze6Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.Department of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.Herbal Medical Research Center, School of Medicine, Yasouj University of Medical Sciences, Yasouj, Iran.Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.This study was aimed to determine prevalence of Vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March 2011 were enrolled in a cross-sectional study. Laboratory analysis including calcium, phosphate, albumin, total and direct bilirubin, aminotransferases, alkalinephosphatase (ALP), prothrombin time (PT), parathyroid hormone (PTH), total protein determined by routine laboratory techniques. Mean age of participants was 299.1 ± 676.8 days (range 2-3600 days) whereas twenty one were female (43.8%) and 27 (56.3%) were male. Twenty two (45.8%) had evidences of rickets in X-ray evaluation. Three children with rickets and two with normal X-ray had Vitamin D deficiency while ten in rickets group and 16 in normal group had Vitamin D insufficiency. The main underlying diseases were anatomical biliary atresia in cases with rickets and idiopathic in other group. Rickets and Vitamin D deficiency should be considered in chronic cholestatic children.https://acta.tums.ac.ir/index.php/acta/article/view/3935RicketsVitamin DChronic cholestasisChildren |
| spellingShingle | Bahram Mohammadi Mehri Najafi Fateme Farahmand Farzaneh Motamed Mahsa Ghajarzadeh Jamshid Mohammadi Mohammad Eshagh Roze Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran Acta Medica Iranica Rickets Vitamin D Chronic cholestasis Children |
| title | Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran |
| title_full | Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran |
| title_fullStr | Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran |
| title_full_unstemmed | Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran |
| title_short | Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran |
| title_sort | prevalence of vitamin d deficiency and rickets in children with cholestasis in iran |
| topic | Rickets Vitamin D Chronic cholestasis Children |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3935 |
| work_keys_str_mv | AT bahrammohammadi prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT mehrinajafi prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT fatemefarahmand prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT farzanehmotamed prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT mahsaghajarzadeh prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT jamshidmohammadi prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran AT mohammadeshaghroze prevalenceofvitaminddeficiencyandricketsinchildrenwithcholestasisiniran |