The role of oestrogen and progesterone receptors in gigantomastia
Introduction Gigantomastia is a rare condition characterised by excessive breast growth. The pathophysiology of mammary enlargement varies depending on the type of gigantomastia: gestational, juvenile virginal, or idiopathic. The study aimed at examining the receptor status (oestrogen receptor alpha...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-09-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-role-of-oestrogen-and-progesterone-receptors-in-gigantomastia,108691,0,2.html |
| _version_ | 1827620306179588096 |
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| author | Anna Kasielska-Trojan Marian Danilewicz Jerzy Strużyna Magdalena Bugaj Bogusław Antoszewski |
| author_facet | Anna Kasielska-Trojan Marian Danilewicz Jerzy Strużyna Magdalena Bugaj Bogusław Antoszewski |
| author_sort | Anna Kasielska-Trojan |
| collection | DOAJ |
| description | Introduction
Gigantomastia is a rare condition characterised by excessive breast growth. The pathophysiology of mammary enlargement varies depending on the type of gigantomastia: gestational, juvenile virginal, or idiopathic. The study aimed at examining the receptor status (oestrogen receptor alpha [ERα] and progesterone receptor [PR]) of breast tissue in adult women with juvenile or idiopathic gigantomastia.
Material and methods
The study involved 70 women who underwent breast reduction due to juvenile or idiopathic gigantomastia. Control breast specimens were obtained from 18 female cadavers. ERα and PR expressions were detected immunohistochemically in breast gland samples.
Results
Categorised and uncategorised ERα and PR expression did not differ between women with gigantomastia and control women. It was found that in both groups weak (0–30%) ERα and PR expression was the most common. Analysis of categorised data also did not reveal any significant correlations between ERα or PR and the women’s age: for the whole group: p = 0.795 (ERα), p = 0.207 (PR), for women with gigantomastia: p = 0.934 (ERα), p = 0.43 (PR), and for control women: p = 0.638 (ERα), p = 0.805 (PR).
Conclusions
Gigantomastia is not caused by increased expression of ERα and PR. Analysing abnormal sensitivity of these receptors to hormones may be crucial in establishing the increased risk of breast cancer in women with gigantomastia. |
| first_indexed | 2024-03-09T10:46:29Z |
| format | Article |
| id | doaj.art-6ec504c1220a4524b5c38724d8b2a79a |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:29Z |
| publishDate | 2019-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-6ec504c1220a4524b5c38724d8b2a79a2023-12-01T10:02:33ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512019-09-011841016102010.5114/aoms.2019.88280108691The role of oestrogen and progesterone receptors in gigantomastiaAnna Kasielska-Trojan0Marian Danilewicz1Jerzy Strużyna2Magdalena Bugaj3Bogusław Antoszewski4Plastic, Reconstructive and Aesthetic Surgery Clinic, Medical University of Lodz, PolandDepartment of Pathology, Medical University of Lodz, PolandEastern Centre of the Burns Treatment and Reconstructive Surgery in Łęczna, PolandEastern Centre of the Burns Treatment and Reconstructive Surgery in Łęczna, PolandPlastic, Reconstructive and Aesthetic Surgery Clinic, Medical University of Lodz, PolandIntroduction Gigantomastia is a rare condition characterised by excessive breast growth. The pathophysiology of mammary enlargement varies depending on the type of gigantomastia: gestational, juvenile virginal, or idiopathic. The study aimed at examining the receptor status (oestrogen receptor alpha [ERα] and progesterone receptor [PR]) of breast tissue in adult women with juvenile or idiopathic gigantomastia. Material and methods The study involved 70 women who underwent breast reduction due to juvenile or idiopathic gigantomastia. Control breast specimens were obtained from 18 female cadavers. ERα and PR expressions were detected immunohistochemically in breast gland samples. Results Categorised and uncategorised ERα and PR expression did not differ between women with gigantomastia and control women. It was found that in both groups weak (0–30%) ERα and PR expression was the most common. Analysis of categorised data also did not reveal any significant correlations between ERα or PR and the women’s age: for the whole group: p = 0.795 (ERα), p = 0.207 (PR), for women with gigantomastia: p = 0.934 (ERα), p = 0.43 (PR), and for control women: p = 0.638 (ERα), p = 0.805 (PR). Conclusions Gigantomastia is not caused by increased expression of ERα and PR. Analysing abnormal sensitivity of these receptors to hormones may be crucial in establishing the increased risk of breast cancer in women with gigantomastia.https://www.archivesofmedicalscience.com/The-role-of-oestrogen-and-progesterone-receptors-in-gigantomastia,108691,0,2.htmloestrogen receptorprogesterone receptorgigantomastia |
| spellingShingle | Anna Kasielska-Trojan Marian Danilewicz Jerzy Strużyna Magdalena Bugaj Bogusław Antoszewski The role of oestrogen and progesterone receptors in gigantomastia Archives of Medical Science oestrogen receptor progesterone receptor gigantomastia |
| title | The role of oestrogen and progesterone receptors in gigantomastia |
| title_full | The role of oestrogen and progesterone receptors in gigantomastia |
| title_fullStr | The role of oestrogen and progesterone receptors in gigantomastia |
| title_full_unstemmed | The role of oestrogen and progesterone receptors in gigantomastia |
| title_short | The role of oestrogen and progesterone receptors in gigantomastia |
| title_sort | role of oestrogen and progesterone receptors in gigantomastia |
| topic | oestrogen receptor progesterone receptor gigantomastia |
| url | https://www.archivesofmedicalscience.com/The-role-of-oestrogen-and-progesterone-receptors-in-gigantomastia,108691,0,2.html |
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