Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

Abstract Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been identified as another important feature contributing to A...

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Bibliographic Details
Main Authors: Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Neuroinflammation
Microglia
Astrocytes
Autophagy
Spermidine
Online Access:https://doi.org/10.1186/s12974-022-02534-7

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