A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

β-amyloid (Aβ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astrocyte response to Aβ plaque subtypes, and investigat...

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Bibliographic Details
Main Authors:	Ryan Mathur, Paul G Ince, Thais Minett, Claire J Garwood, Pamela J Shaw, Fiona E Matthews, Carol Brayne, Julie E Simpson, Stephen B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4338046?pdf=render

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