The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study
Background: Lichen planus is an autoimmune chronic inflammatory condition of unknown etiology affecting stratified squamous epithelial. The cell-mediated immunity has a role in both developing oral lichen planus, and immune system regulation, that’s why have role in the pathogenesis of oral lichen...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-12-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/511 |
| _version_ | 1827636431156150272 |
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| author | Shaheen A Ahmed |
| author_facet | Shaheen A Ahmed |
| author_sort | Shaheen A Ahmed |
| collection | DOAJ |
| description |
Background: Lichen planus is an autoimmune chronic inflammatory condition of unknown etiology affecting stratified squamous epithelial. The cell-mediated immunity has a role in both developing oral lichen planus, and immune system regulation, that’s why have role in the pathogenesis of oral lichen planus. The roles of vitamin D in an immune system and its anti-inflammatory effects have been indicated in recent study.
Objective: To determine the level of serum vitamin D in patients with oral lichen planus and in compression with healthy subjects, and study the relation of serum vitamin D level with clinical types of oral lichen planus, symptom, and demography of oral lichen planus.
Patients and Methods: Two group were designed in this case –control study, the first consist of 40 patients with oral Lichen planus, while the second is control group which include 40 healthy people. A 5-ml blood sample was taken from patients and healthy subjects. The serum vitamin D levels were assessed with a vitamin D total (25-hydroxy vitamin D) kit by employing the electrochemiluminescence technique.
Results: Oral lichen planus mostly affect middle age female, the most common type of oral lichen planus was reticular type (95%) followed by erosive (57.5%) and atrophic oral lichen planus (45%). Mostly oral lichen planus appears on buccal mucosa bilaterally (95%). Vitamin D deficiency was higher in patient with oral lichen planus (60%) and (22.5%) in control group. The control group has more insufficient vitamin D level (22.5%) as compared to oral lichen planus patient(OLP) (15%), which was statistically significant. The mean of vitamin D level in serum of patients with oral lichen planus were 18.84 ±12.69 ng/ml and in healthy subjects were 31.28 ± 13.58ng/ml, that was statistically significant (P< 0.001).
Conclusion: The deficiency in serum vitamin D level was not only related to the development of oral lichen planus, but it was also related to the symptom, and types of oral lichen planus.
DOI:https://doi.org/10.26505/DJM.17024991005
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| first_indexed | 2024-03-09T15:42:52Z |
| format | Article |
| id | doaj.art-6ec83d0b06b34fa590a4bced596207ff |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:42:52Z |
| publishDate | 2019-12-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-6ec83d0b06b34fa590a4bced596207ff2023-11-24T23:23:06ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-12-01172The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control StudyShaheen A Ahmed Background: Lichen planus is an autoimmune chronic inflammatory condition of unknown etiology affecting stratified squamous epithelial. The cell-mediated immunity has a role in both developing oral lichen planus, and immune system regulation, that’s why have role in the pathogenesis of oral lichen planus. The roles of vitamin D in an immune system and its anti-inflammatory effects have been indicated in recent study. Objective: To determine the level of serum vitamin D in patients with oral lichen planus and in compression with healthy subjects, and study the relation of serum vitamin D level with clinical types of oral lichen planus, symptom, and demography of oral lichen planus. Patients and Methods: Two group were designed in this case –control study, the first consist of 40 patients with oral Lichen planus, while the second is control group which include 40 healthy people. A 5-ml blood sample was taken from patients and healthy subjects. The serum vitamin D levels were assessed with a vitamin D total (25-hydroxy vitamin D) kit by employing the electrochemiluminescence technique. Results: Oral lichen planus mostly affect middle age female, the most common type of oral lichen planus was reticular type (95%) followed by erosive (57.5%) and atrophic oral lichen planus (45%). Mostly oral lichen planus appears on buccal mucosa bilaterally (95%). Vitamin D deficiency was higher in patient with oral lichen planus (60%) and (22.5%) in control group. The control group has more insufficient vitamin D level (22.5%) as compared to oral lichen planus patient(OLP) (15%), which was statistically significant. The mean of vitamin D level in serum of patients with oral lichen planus were 18.84 ±12.69 ng/ml and in healthy subjects were 31.28 ± 13.58ng/ml, that was statistically significant (P< 0.001). Conclusion: The deficiency in serum vitamin D level was not only related to the development of oral lichen planus, but it was also related to the symptom, and types of oral lichen planus. DOI:https://doi.org/10.26505/DJM.17024991005 http://djm.uodiyala.edu.iq/index.php/djm/article/view/511Vitamin D deficiency, Lichen planus, Oral lichen planus, Autoimmune diseases. |
| spellingShingle | Shaheen A Ahmed The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study Diyala Journal of Medicine Vitamin D deficiency, Lichen planus, Oral lichen planus, Autoimmune diseases. |
| title | The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study |
| title_full | The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study |
| title_fullStr | The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study |
| title_full_unstemmed | The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study |
| title_short | The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study |
| title_sort | role of serum vitamin d deficency in oral lichen planus case control study |
| topic | Vitamin D deficiency, Lichen planus, Oral lichen planus, Autoimmune diseases. |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/511 |
| work_keys_str_mv | AT shaheenaahmed theroleofserumvitaminddeficencyinorallichenplanuscasecontrolstudy AT shaheenaahmed roleofserumvitaminddeficencyinorallichenplanuscasecontrolstudy |