Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine
Infectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/76 |
| _version_ | 1797491139791552512 |
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| author | Urška Jančič Selestina Gorgieva |
| author_facet | Urška Jančič Selestina Gorgieva |
| author_sort | Urška Jančič |
| collection | DOAJ |
| description | Infectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the increasing spread of diseases in humans and livestock. Promising candidates are natural antimicrobial peptides produced by bacteria, and therapeutic enzymes, extracted from medicinal plants. This review highlights the structure and properties of plant origin bromelain and antimicrobial peptide nisin, along with their mechanism of action, the immobilization strategies, and recent applications in the field of biomedicine. Future perspectives towards the commercialization of new biomedical products, including these important bioactive compounds, have been highlighted. |
| first_indexed | 2024-03-10T00:43:10Z |
| format | Article |
| id | doaj.art-6ec8aec2fc0e43eaabd017c737b1b464 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:43:10Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-6ec8aec2fc0e43eaabd017c737b1b4642023-11-23T15:03:28ZengMDPI AGPharmaceutics1999-49232021-12-011417610.3390/pharmaceutics14010076Bromelain and Nisin: The Natural Antimicrobials with High Potential in BiomedicineUrška Jančič0Selestina Gorgieva1Institute of Engineering Materials and Design, Faculty of Mechanical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, SloveniaInstitute of Engineering Materials and Design, Faculty of Mechanical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, SloveniaInfectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the increasing spread of diseases in humans and livestock. Promising candidates are natural antimicrobial peptides produced by bacteria, and therapeutic enzymes, extracted from medicinal plants. This review highlights the structure and properties of plant origin bromelain and antimicrobial peptide nisin, along with their mechanism of action, the immobilization strategies, and recent applications in the field of biomedicine. Future perspectives towards the commercialization of new biomedical products, including these important bioactive compounds, have been highlighted.https://www.mdpi.com/1999-4923/14/1/76bromelainnisinbioactivityantimicrobial agentbiomedicinecarrier |
| spellingShingle | Urška Jančič Selestina Gorgieva Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine Pharmaceutics bromelain nisin bioactivity antimicrobial agent biomedicine carrier |
| title | Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine |
| title_full | Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine |
| title_fullStr | Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine |
| title_full_unstemmed | Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine |
| title_short | Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine |
| title_sort | bromelain and nisin the natural antimicrobials with high potential in biomedicine |
| topic | bromelain nisin bioactivity antimicrobial agent biomedicine carrier |
| url | https://www.mdpi.com/1999-4923/14/1/76 |
| work_keys_str_mv | AT urskajancic bromelainandnisinthenaturalantimicrobialswithhighpotentialinbiomedicine AT selestinagorgieva bromelainandnisinthenaturalantimicrobialswithhighpotentialinbiomedicine |