Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy
Background: The thalamic gray-white matter ratios (GWRs) on CT and quantitative suppression ratios (SRs) of background activities on EEG may reflect damages in the thalamus and cerebral hemispheres in patients with hypoxic-ischemic encephalopathy (HIE). Methods: The inclusion criteria were (1) cardi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123022595 |
| _version_ | 1797383659568758784 |
|---|---|
| author | GyeongMo Sohn Sung Eun Kim |
| author_facet | GyeongMo Sohn Sung Eun Kim |
| author_sort | GyeongMo Sohn |
| collection | DOAJ |
| description | Background: The thalamic gray-white matter ratios (GWRs) on CT and quantitative suppression ratios (SRs) of background activities on EEG may reflect damages in the thalamus and cerebral hemispheres in patients with hypoxic-ischemic encephalopathy (HIE). Methods: The inclusion criteria were (1) cardiac arrest patients over the age of 20 years from March 2010 to March 2020, and (2) patients who had both EEG and brain CT within 7 days after cardiac arrest. The thalamic GWRs were semi-quantitatively measured by using the region of interest (ROI). SRs of background were analyzed with the installed software (Persyst® v13) in EEG machine. Results: 175 patients were included among 686 patients with HIE and the thalamic GWRs of 168 patients were successfully measured. 155 patients (89 %) showed poor outcomes. The poor outcome group revealed not only higher SRs, but also lower thalamic GWRs. The thalamic GWRs showed a negative correlation to the SRs (ρ (rho) = −0.36, p < 0.0001 for right side, ρ (rho) = −0.31, p < 0.0001 for left side). The good outcome group showed neither beyond the cut-off values of thalamic GWRs nor SRs [40 % (59/148) VS 0 % (0/20) in right side, p = 0.0005 %, and 28 % (42/148) VS 0 % (0/20) in left side, p = 0.0061]. Conclusion: The thalamic GWRs and SRs may reflect the damage in the thalamus and cerebral hemispheres in patients with HIE. Insults in the thalamocortical circuit (TCC) or the thalamus might be responsible for the poor outcome. |
| first_indexed | 2024-03-08T21:24:16Z |
| format | Article |
| id | doaj.art-6ec9cb6057dc40ab80b445c7cbf7e8d3 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T21:24:16Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-6ec9cb6057dc40ab80b445c7cbf7e8d32023-12-21T07:38:32ZengElsevierIBRO Neuroscience Reports2667-24212023-12-0115179185Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathyGyeongMo Sohn0Sung Eun Kim1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaCorrespondence to: Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, Busan 48108, Republic of Korea.; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaBackground: The thalamic gray-white matter ratios (GWRs) on CT and quantitative suppression ratios (SRs) of background activities on EEG may reflect damages in the thalamus and cerebral hemispheres in patients with hypoxic-ischemic encephalopathy (HIE). Methods: The inclusion criteria were (1) cardiac arrest patients over the age of 20 years from March 2010 to March 2020, and (2) patients who had both EEG and brain CT within 7 days after cardiac arrest. The thalamic GWRs were semi-quantitatively measured by using the region of interest (ROI). SRs of background were analyzed with the installed software (Persyst® v13) in EEG machine. Results: 175 patients were included among 686 patients with HIE and the thalamic GWRs of 168 patients were successfully measured. 155 patients (89 %) showed poor outcomes. The poor outcome group revealed not only higher SRs, but also lower thalamic GWRs. The thalamic GWRs showed a negative correlation to the SRs (ρ (rho) = −0.36, p < 0.0001 for right side, ρ (rho) = −0.31, p < 0.0001 for left side). The good outcome group showed neither beyond the cut-off values of thalamic GWRs nor SRs [40 % (59/148) VS 0 % (0/20) in right side, p = 0.0005 %, and 28 % (42/148) VS 0 % (0/20) in left side, p = 0.0061]. Conclusion: The thalamic GWRs and SRs may reflect the damage in the thalamus and cerebral hemispheres in patients with HIE. Insults in the thalamocortical circuit (TCC) or the thalamus might be responsible for the poor outcome.http://www.sciencedirect.com/science/article/pii/S2667242123022595Hypoxic-ischemic encephalopathyPrognosticationThalamic gray-white matter ratiosSuppression ratiosThalamocortical circuit |
| spellingShingle | GyeongMo Sohn Sung Eun Kim Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy IBRO Neuroscience Reports Hypoxic-ischemic encephalopathy Prognostication Thalamic gray-white matter ratios Suppression ratios Thalamocortical circuit |
| title | Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| title_full | Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| title_fullStr | Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| title_full_unstemmed | Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| title_short | Measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| title_sort | measurement of thalamus and cortical damages in hypoxic ischemic encephalopathy |
| topic | Hypoxic-ischemic encephalopathy Prognostication Thalamic gray-white matter ratios Suppression ratios Thalamocortical circuit |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123022595 |
| work_keys_str_mv | AT gyeongmosohn measurementofthalamusandcorticaldamagesinhypoxicischemicencephalopathy AT sungeunkim measurementofthalamusandcorticaldamagesinhypoxicischemicencephalopathy |