Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation
Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 5...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2017-08-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | http://dpcj.org/index.php/dpc/article/view/323 |
| _version_ | 1819227073468694528 |
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| author | Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali |
| author_facet | Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali |
| author_sort | Francesco Lacarrubba |
| collection | DOAJ |
| description | Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover’s disease and showing a Darier-like histopathological pattern is described. Polarized light dermoscopy (PLD) revealed the presence of polygonal, star-like shaped yellowish/brownish areas of various sizes surrounded by a thin whitish halo. Handheld reflectance confocal microscopy (RCM) showed the presence of intraepidermal dark spaces histopathologically corresponding to intraepidermal clefts, roundish, bright cells correlating to acantholytic keratinocytes, target-like cells with a dark center and a highly reflectant halo corresponding to dyskeratotic cells, and epidermal, polygonal, structureless areas reflecting hyperparakeratosis. In conclusion, the use of PLD and RCM combined with clinical presentation, personal/family history, and genetic evaluation may be useful for the non-invasive diagnosis of Darier-like Grover’s disease. |
| first_indexed | 2024-12-23T10:35:35Z |
| format | Article |
| id | doaj.art-6ecab2e3c2244a188fd7a3571a6e2ee2 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-12-23T10:35:35Z |
| publishDate | 2017-08-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-6ecab2e3c2244a188fd7a3571a6e2ee22022-12-21T17:50:18ZengMattioli1885Dermatology Practical & Conceptual2160-93812017-08-017310.5826/dpc.0703a11Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlationFrancesco Lacarrubba0Simona Boscaglia1Maria Rita Nasca2Rosario Caltabiano3Giuseppe Micali4Dermatology Clinic, University of Catania, ItalyDermatology Clinic, University of Catania, ItalyDermatology Clinic, University of Catania, ItalyDepartment “G.F. Ingrassia”, Section of Anatomic Pathology, University of Catania, ItalyDermatology Clinic, University of Catania, ItalyGrover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover’s disease and showing a Darier-like histopathological pattern is described. Polarized light dermoscopy (PLD) revealed the presence of polygonal, star-like shaped yellowish/brownish areas of various sizes surrounded by a thin whitish halo. Handheld reflectance confocal microscopy (RCM) showed the presence of intraepidermal dark spaces histopathologically corresponding to intraepidermal clefts, roundish, bright cells correlating to acantholytic keratinocytes, target-like cells with a dark center and a highly reflectant halo corresponding to dyskeratotic cells, and epidermal, polygonal, structureless areas reflecting hyperparakeratosis. In conclusion, the use of PLD and RCM combined with clinical presentation, personal/family history, and genetic evaluation may be useful for the non-invasive diagnosis of Darier-like Grover’s disease.http://dpcj.org/index.php/dpc/article/view/323reflectance confocal microscopydermoscopyGrover’s diseaseDarier’s diseaseacantholysiscorp ronds |
| spellingShingle | Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation Dermatology Practical & Conceptual reflectance confocal microscopy dermoscopy Grover’s disease Darier’s disease acantholysis corp ronds |
| title | Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_full | Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_fullStr | Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_full_unstemmed | Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_short | Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_sort | grover s disease dermoscopy reflectance confocal microscopy and histopathological correlation |
| topic | reflectance confocal microscopy dermoscopy Grover’s disease Darier’s disease acantholysis corp ronds |
| url | http://dpcj.org/index.php/dpc/article/view/323 |
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