The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more. The JAK/STAT signaling pathway extensively mediates various biological processes such as cell proliferation, dif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/119 |
| _version_ | 1797445473672364032 |
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| author | Jia Liu Faping Wang Fengming Luo |
| author_facet | Jia Liu Faping Wang Fengming Luo |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more. The JAK/STAT signaling pathway extensively mediates various biological processes such as cell proliferation, differentiation, migration, apoptosis, and immune regulation. JAK/STAT activation is closely related to growth and development, homeostasis, various solid tumors, inflammatory illness, and autoimmune diseases. Recently, with the deepening understanding of the JAK/STAT pathway, the relationship between JAK/STAT and the pathophysiology of fibrotic diseases was noticed, including the liver, renal, heart, bone marrow, and lung. JAK inhibitor has been approved for myelofibrosis, and subsequently, JAK/STAT may serve as a promising target for fibrosis in other organs. Therefore, this article reviews the roles and mechanisms of the JAK/STAT signaling pathway in fibrotic diseases. |
| first_indexed | 2024-03-09T13:26:18Z |
| format | Article |
| id | doaj.art-6ecabc731e4d4b21a77516d73602c756 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:26:18Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6ecabc731e4d4b21a77516d73602c7562023-11-30T21:23:02ZengMDPI AGBiomolecules2218-273X2023-01-0113111910.3390/biom13010119The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular MechanismsJia Liu0Faping Wang1Fengming Luo2Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaThere are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more. The JAK/STAT signaling pathway extensively mediates various biological processes such as cell proliferation, differentiation, migration, apoptosis, and immune regulation. JAK/STAT activation is closely related to growth and development, homeostasis, various solid tumors, inflammatory illness, and autoimmune diseases. Recently, with the deepening understanding of the JAK/STAT pathway, the relationship between JAK/STAT and the pathophysiology of fibrotic diseases was noticed, including the liver, renal, heart, bone marrow, and lung. JAK inhibitor has been approved for myelofibrosis, and subsequently, JAK/STAT may serve as a promising target for fibrosis in other organs. Therefore, this article reviews the roles and mechanisms of the JAK/STAT signaling pathway in fibrotic diseases.https://www.mdpi.com/2218-273X/13/1/119Janus kinases (JAK)signal transducer and activator of transcription (STAT)cytokinesfibrosisfibroblastinhibitor |
| spellingShingle | Jia Liu Faping Wang Fengming Luo The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms Biomolecules Janus kinases (JAK) signal transducer and activator of transcription (STAT) cytokines fibrosis fibroblast inhibitor |
| title | The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms |
| title_full | The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms |
| title_fullStr | The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms |
| title_full_unstemmed | The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms |
| title_short | The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms |
| title_sort | role of jak stat pathway in fibrotic diseases molecular and cellular mechanisms |
| topic | Janus kinases (JAK) signal transducer and activator of transcription (STAT) cytokines fibrosis fibroblast inhibitor |
| url | https://www.mdpi.com/2218-273X/13/1/119 |
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