Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China
Abstract Background Less is known about the risk factors for acute respiratory distress syndrome (ARDS) in sepsis patients diagnosed according to sepsis 3.0 criteria. Moreover, the risk factors for ARDS severity remain unclear. Methods We retrospectively collected the characteristics of sepsis patie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02015-w |
| _version_ | 1818550447487582208 |
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| author | Yuequan Shi Liang Wang Sihan Yu Xiaochun Ma Xu Li |
| author_facet | Yuequan Shi Liang Wang Sihan Yu Xiaochun Ma Xu Li |
| author_sort | Yuequan Shi |
| collection | DOAJ |
| description | Abstract Background Less is known about the risk factors for acute respiratory distress syndrome (ARDS) in sepsis patients diagnosed according to sepsis 3.0 criteria. Moreover, the risk factors for ARDS severity remain unclear. Methods We retrospectively collected the characteristics of sepsis patients from the intensive care unit of the First Affiliated Hospital of China Medical University from January 2017 to September 2018. Logistic regression was used in determining the risk factors. Results 529 patients with sepsis were enrolled and 179 developed ARDS. The most common infection sites were acute abdominal infection (n = 304) and pneumonia (n = 117). Multivariate analysis showed that patients with pancreatitis with local infection (odds ratio [OR], 3.601; 95% confidence interval [CI], 1.429–9.073, P = 0.007), pneumonia (OR 3.486; 95% CI 1.890–6.430, P < 0.001), septic shock (OR 2.163; 95% CI 1.429–3.275, P < 0.001), a higher sequential organ failure assessment (SOFA) score (OR 1.241; 95% CI 1.155–1.333, P < 0.001) and non-pulmonary SOFA score (OR 2.849; 95% CI 2.113–3.841, P < 0.001) were independent risk factors for ARDS. Moreover, pneumonia is associated with increased severity of ARDS (OR 2.512; 95% CI 1.039–6.067, P = 0.041). Conclusions We determined five risk factors for ARDS in sepsis patients. Moreover, pneumonia is significantly associated with an increased severity of ARDS. |
| first_indexed | 2024-12-12T08:46:36Z |
| format | Article |
| id | doaj.art-6ecd4ccfeeac4f03a520368dde0bb6b3 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-12T08:46:36Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-6ecd4ccfeeac4f03a520368dde0bb6b32022-12-22T00:30:30ZengBMCBMC Pulmonary Medicine1471-24662022-06-012211910.1186/s12890-022-02015-wRisk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in ChinaYuequan Shi0Liang Wang1Sihan Yu2Xiaochun Ma3Xu Li4Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Critical Care Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Critical Care Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Critical Care Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Critical Care Medicine, The First Affiliated Hospital of China Medical UniversityAbstract Background Less is known about the risk factors for acute respiratory distress syndrome (ARDS) in sepsis patients diagnosed according to sepsis 3.0 criteria. Moreover, the risk factors for ARDS severity remain unclear. Methods We retrospectively collected the characteristics of sepsis patients from the intensive care unit of the First Affiliated Hospital of China Medical University from January 2017 to September 2018. Logistic regression was used in determining the risk factors. Results 529 patients with sepsis were enrolled and 179 developed ARDS. The most common infection sites were acute abdominal infection (n = 304) and pneumonia (n = 117). Multivariate analysis showed that patients with pancreatitis with local infection (odds ratio [OR], 3.601; 95% confidence interval [CI], 1.429–9.073, P = 0.007), pneumonia (OR 3.486; 95% CI 1.890–6.430, P < 0.001), septic shock (OR 2.163; 95% CI 1.429–3.275, P < 0.001), a higher sequential organ failure assessment (SOFA) score (OR 1.241; 95% CI 1.155–1.333, P < 0.001) and non-pulmonary SOFA score (OR 2.849; 95% CI 2.113–3.841, P < 0.001) were independent risk factors for ARDS. Moreover, pneumonia is associated with increased severity of ARDS (OR 2.512; 95% CI 1.039–6.067, P = 0.041). Conclusions We determined five risk factors for ARDS in sepsis patients. Moreover, pneumonia is significantly associated with an increased severity of ARDS.https://doi.org/10.1186/s12890-022-02015-wAcute respiratory distress syndromeSepsisRisk factorSeverity |
| spellingShingle | Yuequan Shi Liang Wang Sihan Yu Xiaochun Ma Xu Li Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China BMC Pulmonary Medicine Acute respiratory distress syndrome Sepsis Risk factor Severity |
| title | Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China |
| title_full | Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China |
| title_fullStr | Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China |
| title_full_unstemmed | Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China |
| title_short | Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China |
| title_sort | risk factors for acute respiratory distress syndrome in sepsis patients a retrospective study from a tertiary hospital in china |
| topic | Acute respiratory distress syndrome Sepsis Risk factor Severity |
| url | https://doi.org/10.1186/s12890-022-02015-w |
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