Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer
Background Annexin 1 (ANXA1) expression is associated with the malignant tumor phenotype, making it an attractive therapeutic target. However, little is known about the regulation of ANXA1 in non‐small cell lung cancer (NSCLC). Methods We investigated the biological roles of ANXA1 in tumor growth, m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-04-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.12982 |
| _version_ | 1797845473022705664 |
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| author | Xiaoying Guan Ying Fang Jie Long Yajie Zhang |
| author_facet | Xiaoying Guan Ying Fang Jie Long Yajie Zhang |
| author_sort | Xiaoying Guan |
| collection | DOAJ |
| description | Background Annexin 1 (ANXA1) expression is associated with the malignant tumor phenotype, making it an attractive therapeutic target. However, little is known about the regulation of ANXA1 in non‐small cell lung cancer (NSCLC). Methods We investigated the biological roles of ANXA1 in tumor growth, migration, and invasion, and explored the possibility of ANXA1 as a potential therapeutic target for the treatment of NSCLC. Results Our findings revealed that ANXA1 enhanced nuclear factor (NF)‐κB activation in NSCLC cells by interaction with inhibitor of NF‐κB kinase complex subunit, IKKγ. We also found that NF‐κB could negatively regulate microRNA (miR)‐26a, and miR‐26a was regulated through the ANXA1–NF‐κB regulatory pathway. NF‐κB activation negatively regulated by miR‐26a was confirmed in NSCLC. Conclusion Together, these results provide evidence of the mechanisms of the ANXA1–NF‐κB–miR‐26a regulatory pathway in the invasion and migration in NSCLC. |
| first_indexed | 2024-04-09T17:39:35Z |
| format | Article |
| id | doaj.art-6ecd9ebbe7ee4dba9031f243fa587eb5 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-09T17:39:35Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-6ecd9ebbe7ee4dba9031f243fa587eb52023-04-17T06:34:28ZengWileyThoracic Cancer1759-77061759-77142019-04-0110466567510.1111/1759-7714.12982Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancerXiaoying Guan0Ying Fang1Jie Long2Yajie Zhang3Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease Affiliated Stomatology Hospital of Guangzhou Medical University Guangzhou ChinaDepartment of Pathology, School of Basic Medical Science Guangzhou Medical University Xinzao ChinaDepartment of Pathology, School of Basic Medical Science Guangzhou Medical University Xinzao ChinaDepartment of Pathology, School of Basic Medical Science Guangzhou Medical University Xinzao ChinaBackground Annexin 1 (ANXA1) expression is associated with the malignant tumor phenotype, making it an attractive therapeutic target. However, little is known about the regulation of ANXA1 in non‐small cell lung cancer (NSCLC). Methods We investigated the biological roles of ANXA1 in tumor growth, migration, and invasion, and explored the possibility of ANXA1 as a potential therapeutic target for the treatment of NSCLC. Results Our findings revealed that ANXA1 enhanced nuclear factor (NF)‐κB activation in NSCLC cells by interaction with inhibitor of NF‐κB kinase complex subunit, IKKγ. We also found that NF‐κB could negatively regulate microRNA (miR)‐26a, and miR‐26a was regulated through the ANXA1–NF‐κB regulatory pathway. NF‐κB activation negatively regulated by miR‐26a was confirmed in NSCLC. Conclusion Together, these results provide evidence of the mechanisms of the ANXA1–NF‐κB–miR‐26a regulatory pathway in the invasion and migration in NSCLC.https://doi.org/10.1111/1759-7714.12982Annexin 1microRNA‐26anuclear factor‐κB pathwaynon‐small cell lung carcinoma |
| spellingShingle | Xiaoying Guan Ying Fang Jie Long Yajie Zhang Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer Thoracic Cancer Annexin 1 microRNA‐26a nuclear factor‐κB pathway non‐small cell lung carcinoma |
| title | Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer |
| title_full | Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer |
| title_fullStr | Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer |
| title_full_unstemmed | Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer |
| title_short | Annexin 1–nuclear factor‐κB–microRNA‐26a regulatory pathway in the metastasis of non‐small cell lung cancer |
| title_sort | annexin 1 nuclear factor κb microrna 26a regulatory pathway in the metastasis of non small cell lung cancer |
| topic | Annexin 1 microRNA‐26a nuclear factor‐κB pathway non‐small cell lung carcinoma |
| url | https://doi.org/10.1111/1759-7714.12982 |
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