Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-codin...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/22/5651 |
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| author | Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín |
| author_facet | Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín |
| author_sort | Eleftheria Papaioannou |
| collection | DOAJ |
| description | Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy. |
| first_indexed | 2024-03-10T05:39:21Z |
| format | Article |
| id | doaj.art-6ecda2189d324e51940a23ef0df72c33 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:39:21Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6ecda2189d324e51940a23ef0df72c332023-11-22T22:41:17ZengMDPI AGCancers2072-66942021-11-011322565110.3390/cancers13225651Regulation of Adaptive Tumor Immunity by Non-Coding RNAsEleftheria Papaioannou0María del Pilar González-Molina1Ana M. Prieto-Muñoz2Laura Gámez-Reche3Alicia González-Martín4Department of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, SpainDepartment of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, SpainDepartment of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, SpainDepartment of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, SpainDepartment of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, SpainCancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy.https://www.mdpi.com/2072-6694/13/22/5651tumor immunologynon-coding RNAsmicroRNAslong non-coding RNAscancer immunotherapy |
| spellingShingle | Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín Regulation of Adaptive Tumor Immunity by Non-Coding RNAs Cancers tumor immunology non-coding RNAs microRNAs long non-coding RNAs cancer immunotherapy |
| title | Regulation of Adaptive Tumor Immunity by Non-Coding RNAs |
| title_full | Regulation of Adaptive Tumor Immunity by Non-Coding RNAs |
| title_fullStr | Regulation of Adaptive Tumor Immunity by Non-Coding RNAs |
| title_full_unstemmed | Regulation of Adaptive Tumor Immunity by Non-Coding RNAs |
| title_short | Regulation of Adaptive Tumor Immunity by Non-Coding RNAs |
| title_sort | regulation of adaptive tumor immunity by non coding rnas |
| topic | tumor immunology non-coding RNAs microRNAs long non-coding RNAs cancer immunotherapy |
| url | https://www.mdpi.com/2072-6694/13/22/5651 |
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