Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study
PURPOSETo evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer sy...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2023-09-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.23.00006 |
| _version_ | 1797401079742201856 |
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| author | Juliana Giacomazzi Patricia Klarmann Ziegelmann Samanta da Costa Camila Matzenbacher Bittar Fernando Mariano Obst Clévia Rosset Gabriel S. Macedo Hugo Bock Thais Canal Mari Ines Paese Jean Lucas Benvenuti Maria Carolina Buj Patricia Ashton-Prolla José Roberto Goldim Roberta Pozza |
| author_facet | Juliana Giacomazzi Patricia Klarmann Ziegelmann Samanta da Costa Camila Matzenbacher Bittar Fernando Mariano Obst Clévia Rosset Gabriel S. Macedo Hugo Bock Thais Canal Mari Ines Paese Jean Lucas Benvenuti Maria Carolina Buj Patricia Ashton-Prolla José Roberto Goldim Roberta Pozza |
| author_sort | Juliana Giacomazzi |
| collection | DOAJ |
| description | PURPOSETo evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome (HCS) phenotypes.METHODSA case-control (matched by age group and sex) study was conducted on regional cancer. Data on exposure factors and first-/second-degree family history of cancer (1/2FHC) were collected. The MGPT was performed using Illumina next-generation sequencing technology.RESULTSA total of 1,007 cases and 1,007 controls were included. The most frequent cancers were BC (n = 311), CCR (n = 147), prostate (n = 132), and lung cancers (n = 89). It was independently associated with cancer, 1/2FHC, tobacco consumption (TC), pesticide exposure (PE), solvent/glue exposure, and BMI <24. BC was associated with 1/2FHC, TC, and hormone replacement therapy use; CCR with 1/2FHC, TC, and BMI <24; prostate cancer with 1/2FHC, TC, and alcohol consumption; and lung cancer with 1/2FHC, TC, PE, and BMI <24. MGPT identified pathogenic/likely pathogenic mutations in 24 (32%) women with BC and in three (18%) women and four (24%) men diagnosed with CCR at under 50 years. Among the tested patients under 50 years with diagnosed BC and CCR, 98.6% and 97% present criteria for HCS, respectively.CONCLUSIONThis study confirmed the association of several factors associated with BC, CCR, prostate, and lung cancers and reinforced the importance of evaluating FHC and genetic testing, especially for patients under 50 years with diagnosed BC or CCR. A better understanding of population-specific cancer risk factors builds on sustainable data for developing prevention strategies. These efforts increase the commitment to early detection and surveillance. |
| first_indexed | 2024-03-09T02:04:40Z |
| format | Article |
| id | doaj.art-6ecf9af14bc44aa09e5bcac27e848684 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-03-09T02:04:40Z |
| publishDate | 2023-09-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-6ecf9af14bc44aa09e5bcac27e8486842023-12-07T20:59:25ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412023-09-01910.1200/GO.23.00006Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control StudyJuliana Giacomazzi0Patricia Klarmann Ziegelmann1Samanta da Costa2Camila Matzenbacher Bittar3Fernando Mariano Obst4Clévia Rosset5Gabriel S. Macedo6Hugo Bock7Thais Canal8Mari Ines Paese9Jean Lucas Benvenuti10Maria Carolina Buj11Patricia Ashton-Prolla12José Roberto Goldim13Roberta Pozza14Instituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilPrograma de Pós-graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilInstituto do Câncer, Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilLaboratório de Medicina Genômica, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilLaboratório de Medicina Genômica, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilUnidade de Pesquisa Laboratorial, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilLaboratório de Medicina Genômica, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilServiço de Bioética, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilInstituto Tacchini de Pesquisa em Saúde/Hospital Tacchini, Tacchini Sistema de Saúde, Bento Gonçalves, BrazilPURPOSETo evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome (HCS) phenotypes.METHODSA case-control (matched by age group and sex) study was conducted on regional cancer. Data on exposure factors and first-/second-degree family history of cancer (1/2FHC) were collected. The MGPT was performed using Illumina next-generation sequencing technology.RESULTSA total of 1,007 cases and 1,007 controls were included. The most frequent cancers were BC (n = 311), CCR (n = 147), prostate (n = 132), and lung cancers (n = 89). It was independently associated with cancer, 1/2FHC, tobacco consumption (TC), pesticide exposure (PE), solvent/glue exposure, and BMI <24. BC was associated with 1/2FHC, TC, and hormone replacement therapy use; CCR with 1/2FHC, TC, and BMI <24; prostate cancer with 1/2FHC, TC, and alcohol consumption; and lung cancer with 1/2FHC, TC, PE, and BMI <24. MGPT identified pathogenic/likely pathogenic mutations in 24 (32%) women with BC and in three (18%) women and four (24%) men diagnosed with CCR at under 50 years. Among the tested patients under 50 years with diagnosed BC and CCR, 98.6% and 97% present criteria for HCS, respectively.CONCLUSIONThis study confirmed the association of several factors associated with BC, CCR, prostate, and lung cancers and reinforced the importance of evaluating FHC and genetic testing, especially for patients under 50 years with diagnosed BC or CCR. A better understanding of population-specific cancer risk factors builds on sustainable data for developing prevention strategies. These efforts increase the commitment to early detection and surveillance.https://ascopubs.org/doi/10.1200/GO.23.00006 |
| spellingShingle | Juliana Giacomazzi Patricia Klarmann Ziegelmann Samanta da Costa Camila Matzenbacher Bittar Fernando Mariano Obst Clévia Rosset Gabriel S. Macedo Hugo Bock Thais Canal Mari Ines Paese Jean Lucas Benvenuti Maria Carolina Buj Patricia Ashton-Prolla José Roberto Goldim Roberta Pozza Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study JCO Global Oncology |
| title | Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| title_full | Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| title_fullStr | Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| title_full_unstemmed | Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| title_short | Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study |
| title_sort | cancer risk factors in southern brazil report of a comprehensive matched case control study |
| url | https://ascopubs.org/doi/10.1200/GO.23.00006 |
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