Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study
Magnetic resonance imaging (MRI) in patients with breast cancer to assess extent of disease or multifocal disease can demonstrate indeterminate lesions requiring second-look ultrasound and ultrasound or MRI-guided biopsies. Prone positron emission tomography-computed tomography (PET-CT) is a dedicat...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/10/4/148 |
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| author | Anmol Malhotra Sophia Tincey Vishnu Naidu Carla Papagiorcopulo Debashis Ghosh Peng H. Tan Fred Wickham Thomas Wagner |
| author_facet | Anmol Malhotra Sophia Tincey Vishnu Naidu Carla Papagiorcopulo Debashis Ghosh Peng H. Tan Fred Wickham Thomas Wagner |
| author_sort | Anmol Malhotra |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) in patients with breast cancer to assess extent of disease or multifocal disease can demonstrate indeterminate lesions requiring second-look ultrasound and ultrasound or MRI-guided biopsies. Prone positron emission tomography-computed tomography (PET-CT) is a dedicated acquisition performed with a breast-supporting device on a standard PET-CT scanner. The MAMmography with Molecular Imaging (MAMMI, Oncovision, Valencia, Spain) PET system (PET-MAMMI) is a true tomographic ring scanner for the breast. We investigated if PET-MAMMI and prone PET-CT were able to characterise these MRI- indeterminate lesions further. A total of 10 patients with breast cancer and indeterminate lesions on breast MRI were included. Patients underwent prone PET-MAMMI and prone PET-CT after injection of FDG subsequently on the same day. Patients then resumed their normal pathway, with the clinicians blinded to the results of the PET-MAMMI and prone PET-CT. Of the MRI-indeterminate lesions, eight were histopathologically proven to be malignant and two were benign. PET-MAMMI and prone PET-CT only were able to demonstrate increased FDG uptake in 1/8 and 0/8 of the MRI-indeterminate malignant lesions, respectively. Of the MRI-indeterminate benign lesions, both PET-MAMMI and prone PET-CT demonstrated avidity in 1/2 of these lesions. Our findings do not support the use of PET-MAMMI to characterise indeterminate breast MRI lesions requiring a second look ultrasound. |
| first_indexed | 2024-03-10T16:02:43Z |
| format | Article |
| id | doaj.art-6ecfbae92e1d4faf92e179f92d411577 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T16:02:43Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6ecfbae92e1d4faf92e179f92d4115772023-11-20T15:09:49ZengMDPI AGJournal of Personalized Medicine2075-44262020-09-0110414810.3390/jpm10040148Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept StudyAnmol Malhotra0Sophia Tincey1Vishnu Naidu2Carla Papagiorcopulo3Debashis Ghosh4Peng H. Tan5Fred Wickham6Thomas Wagner7Radiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKRadiology Department, Royal Free Hospital NHS Trust, London NW3 2QG, UKMagnetic resonance imaging (MRI) in patients with breast cancer to assess extent of disease or multifocal disease can demonstrate indeterminate lesions requiring second-look ultrasound and ultrasound or MRI-guided biopsies. Prone positron emission tomography-computed tomography (PET-CT) is a dedicated acquisition performed with a breast-supporting device on a standard PET-CT scanner. The MAMmography with Molecular Imaging (MAMMI, Oncovision, Valencia, Spain) PET system (PET-MAMMI) is a true tomographic ring scanner for the breast. We investigated if PET-MAMMI and prone PET-CT were able to characterise these MRI- indeterminate lesions further. A total of 10 patients with breast cancer and indeterminate lesions on breast MRI were included. Patients underwent prone PET-MAMMI and prone PET-CT after injection of FDG subsequently on the same day. Patients then resumed their normal pathway, with the clinicians blinded to the results of the PET-MAMMI and prone PET-CT. Of the MRI-indeterminate lesions, eight were histopathologically proven to be malignant and two were benign. PET-MAMMI and prone PET-CT only were able to demonstrate increased FDG uptake in 1/8 and 0/8 of the MRI-indeterminate malignant lesions, respectively. Of the MRI-indeterminate benign lesions, both PET-MAMMI and prone PET-CT demonstrated avidity in 1/2 of these lesions. Our findings do not support the use of PET-MAMMI to characterise indeterminate breast MRI lesions requiring a second look ultrasound.https://www.mdpi.com/2075-4426/10/4/148MRI-indeterminate breast lesionPET-MAMMIprone PET-CT |
| spellingShingle | Anmol Malhotra Sophia Tincey Vishnu Naidu Carla Papagiorcopulo Debashis Ghosh Peng H. Tan Fred Wickham Thomas Wagner Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study Journal of Personalized Medicine MRI-indeterminate breast lesion PET-MAMMI prone PET-CT |
| title | Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study |
| title_full | Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study |
| title_fullStr | Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study |
| title_full_unstemmed | Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study |
| title_short | Characterisation of MRI Indeterminate Breast Lesions Using Dedicated Breast PET and Prone FDG PET-CT in Patients with Breast Cancer—A Proof-of-Concept Study |
| title_sort | characterisation of mri indeterminate breast lesions using dedicated breast pet and prone fdg pet ct in patients with breast cancer a proof of concept study |
| topic | MRI-indeterminate breast lesion PET-MAMMI prone PET-CT |
| url | https://www.mdpi.com/2075-4426/10/4/148 |
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