The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population
Abstract Aims Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods In this case–control study, four single‐nucleotide polymorphisms of CYP24A1 w...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1503 |
| _version_ | 1818335472338862080 |
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| author | Wei Yang Fenghui Ma Li Wang Xue He Hengxun Zhang Jianwen Zheng Yuhe Wang Tianbo Jin Dongya Yuan Yongjun He |
| author_facet | Wei Yang Fenghui Ma Li Wang Xue He Hengxun Zhang Jianwen Zheng Yuhe Wang Tianbo Jin Dongya Yuan Yongjun He |
| author_sort | Wei Yang |
| collection | DOAJ |
| description | Abstract Aims Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods In this case–control study, four single‐nucleotide polymorphisms of CYP24A1 were selected and genotyped by MassARRAY platform in Chinese Han population. Odds ratios and 95% confidence intervals were calculated via logistic regression analysis with adjustment in genetic models. Results Our results indicated that CYP24A1 variant (rs1570669) was associated with the decreased risk of ischemic stroke (OR = 0.60, p < .001). Stratification analysis showed that the rs6068816 could enhance the ischemic stroke risk by 1.64 times (OR = 1.64, p = .028), while rs1570669 played protective role (OR = 0.63, p = .044) in age >64 years. The rs2762934 had an increased ischemic stroke susceptibility (OR = 1.62, p = .033); however, rs1570669 might reduce stroke risk (OR = 0.61, p = .015) in age ≤64 years. The rs1570669 depressed ischemic stroke susceptibility both in female and male patients (OR = 0.46, p = .002; OR = 0.69, p = .033, respectively), and rs2296241 would weaken the risk in male (OR = 0.63, p = .012). The rs1570669 was associated with decreased risk of ischemic stroke with hypertension (OR = 0.56, p = .042). Conclusion Our study gave the evidences that CYP24A1 genetic polymorphisms were significantly associated with ischemic stroke patients, which would provide useful information of assessment or possible diagnostic markers for ischemic stroke. |
| first_indexed | 2024-12-13T14:23:58Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-13T14:23:58Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj.art-6ed07a2781064f96b455f9349cf87a182022-12-21T23:41:59ZengWileyBrain and Behavior2162-32792020-02-01102n/an/a10.1002/brb3.1503The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han populationWei Yang0Fenghui Ma1Li Wang2Xue He3Hengxun Zhang4Jianwen Zheng5Yuhe Wang6Tianbo Jin7Dongya Yuan8Yongjun He9Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaMedical Examination Center Tangdu Hospital the Fourth Military Medical University Xi’an ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang ChinaAbstract Aims Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods In this case–control study, four single‐nucleotide polymorphisms of CYP24A1 were selected and genotyped by MassARRAY platform in Chinese Han population. Odds ratios and 95% confidence intervals were calculated via logistic regression analysis with adjustment in genetic models. Results Our results indicated that CYP24A1 variant (rs1570669) was associated with the decreased risk of ischemic stroke (OR = 0.60, p < .001). Stratification analysis showed that the rs6068816 could enhance the ischemic stroke risk by 1.64 times (OR = 1.64, p = .028), while rs1570669 played protective role (OR = 0.63, p = .044) in age >64 years. The rs2762934 had an increased ischemic stroke susceptibility (OR = 1.62, p = .033); however, rs1570669 might reduce stroke risk (OR = 0.61, p = .015) in age ≤64 years. The rs1570669 depressed ischemic stroke susceptibility both in female and male patients (OR = 0.46, p = .002; OR = 0.69, p = .033, respectively), and rs2296241 would weaken the risk in male (OR = 0.63, p = .012). The rs1570669 was associated with decreased risk of ischemic stroke with hypertension (OR = 0.56, p = .042). Conclusion Our study gave the evidences that CYP24A1 genetic polymorphisms were significantly associated with ischemic stroke patients, which would provide useful information of assessment or possible diagnostic markers for ischemic stroke.https://doi.org/10.1002/brb3.1503CYP24A1genetic polymorphismsischemic stroke |
| spellingShingle | Wei Yang Fenghui Ma Li Wang Xue He Hengxun Zhang Jianwen Zheng Yuhe Wang Tianbo Jin Dongya Yuan Yongjun He The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population Brain and Behavior CYP24A1 genetic polymorphisms ischemic stroke |
| title | The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population |
| title_full | The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population |
| title_fullStr | The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population |
| title_full_unstemmed | The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population |
| title_short | The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population |
| title_sort | association analysis between cyp24a1 genetic polymorphisms and the risk of ischemic stroke in chinese han population |
| topic | CYP24A1 genetic polymorphisms ischemic stroke |
| url | https://doi.org/10.1002/brb3.1503 |
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