A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice

A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice

Atherosclerosis is a chronic inflammatory disease of the arterial walls that develops at predisposed sites. As a major risk factor for adverse cardiovascular pathology, atherosclerosis can progress to myocardial infarction and stroke, due to the rupture of unstable atherosclerotic lesions. Macrophag...

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Bibliographic Details
Main Authors: Jade Gauvin, Geneviève Frégeau, Hanan Elimam, Liliane Ménard, David Huynh, Catherine Lê, Ahsanullah Ahsanullah, William D. Lubell, Huy Ong, Sylvie Marleau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
CD36
azapeptide
lesion stability
efferocytosis
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1204905/full

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