Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.

Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.

Pericentric heterochromatin, while often considered as "junk" DNA, plays important functions in chromosome biology. It contributes to sister chromatid cohesion, a process mediated by the cohesin complex that ensures proper genome segregation during nuclear division. Long stretches of heter...

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Bibliographic Details
Main Authors: Raquel A Oliveira, Shaila Kotadia, Alexandra Tavares, Mihailo Mirkovic, Katherine Bowlin, Christian S Eichinger, Kim Nasmyth, William Sullivan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4188515?pdf=render

Internet

http://europepmc.org/articles/PMC4188515?pdf=render

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