Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations
The recent COVID-19 pandemic has propelled the field of aerosol science to the forefront, particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic has also highlighted the critical need, and value for, an information bridge between epidemiological models (that inf...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.923945/full |
| _version_ | 1818236205181960192 |
|---|---|
| author | Chantal Darquenne Azadeh A.T. Borojeni Mitchel J. Colebank M. Gregory Forest Balázs G. Madas Merryn Tawhai Yi Jiang |
| author_facet | Chantal Darquenne Azadeh A.T. Borojeni Mitchel J. Colebank M. Gregory Forest Balázs G. Madas Merryn Tawhai Yi Jiang |
| author_sort | Chantal Darquenne |
| collection | DOAJ |
| description | The recent COVID-19 pandemic has propelled the field of aerosol science to the forefront, particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic has also highlighted the critical need, and value for, an information bridge between epidemiological models (that inform policymakers to develop public health responses) and within-host models (that inform the public and health care providers how individuals develop respiratory infections). Here, we review existing data and models of generation of respiratory droplets and aerosols, their exhalation and inhalation, and the fate of infectious droplet transport and deposition throughout the respiratory tract. We then articulate how aerosol transport modeling can serve as a bridge between and guide calibration of within-host and epidemiological models, forming a comprehensive tool to formulate and test hypotheses about respiratory tract exposure and infection within and between individuals. |
| first_indexed | 2024-12-12T12:06:10Z |
| format | Article |
| id | doaj.art-6ed1dc9e6e7d4e3e81fa2e08efa72f2b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T12:06:10Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-6ed1dc9e6e7d4e3e81fa2e08efa72f2b2022-12-22T00:25:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.923945923945Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and PopulationsChantal Darquenne0Azadeh A.T. Borojeni1Mitchel J. Colebank2M. Gregory Forest3Balázs G. Madas4Merryn Tawhai5Yi Jiang6Department of Medicine, University of California, San Diego, San Diego, CA, United StatesDepartment of Medicine, University of California, San Diego, San Diego, CA, United StatesEdwards Lifesciences Foundation Cardiovascular Innovation and Research Center and Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, United StatesDepartments of Mathematics, Applied Physical Sciences, and Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesEnvironmental Physics Department, Centre for Energy Research, Budapest, HungaryAuckland Bioengineering Institute, University of Auckland, Auckland, New ZealandDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, United StatesThe recent COVID-19 pandemic has propelled the field of aerosol science to the forefront, particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic has also highlighted the critical need, and value for, an information bridge between epidemiological models (that inform policymakers to develop public health responses) and within-host models (that inform the public and health care providers how individuals develop respiratory infections). Here, we review existing data and models of generation of respiratory droplets and aerosols, their exhalation and inhalation, and the fate of infectious droplet transport and deposition throughout the respiratory tract. We then articulate how aerosol transport modeling can serve as a bridge between and guide calibration of within-host and epidemiological models, forming a comprehensive tool to formulate and test hypotheses about respiratory tract exposure and infection within and between individuals.https://www.frontiersin.org/articles/10.3389/fphys.2022.923945/fullrespiratory dropletsaerosol depositionmucociliary clearancerespiratory tract infectionpublic health |
| spellingShingle | Chantal Darquenne Azadeh A.T. Borojeni Mitchel J. Colebank M. Gregory Forest Balázs G. Madas Merryn Tawhai Yi Jiang Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations Frontiers in Physiology respiratory droplets aerosol deposition mucociliary clearance respiratory tract infection public health |
| title | Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations |
| title_full | Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations |
| title_fullStr | Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations |
| title_full_unstemmed | Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations |
| title_short | Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations |
| title_sort | aerosol transport modeling the key link between lung infections of individuals and populations |
| topic | respiratory droplets aerosol deposition mucociliary clearance respiratory tract infection public health |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.923945/full |
| work_keys_str_mv | AT chantaldarquenne aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT azadehatborojeni aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT mitcheljcolebank aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT mgregoryforest aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT balazsgmadas aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT merryntawhai aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations AT yijiang aerosoltransportmodelingthekeylinkbetweenlunginfectionsofindividualsandpopulations |