Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis
Objective: Although some meta-analyses have shown a correlation between a high neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with gliomas, their conclusions are controversial, and no study has specifically explored the relationship between a high pre-treatment and pre-operative N...
| Main Authors: | , , , |
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/675 |
| _version_ | 1797501173352103936 |
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| author | Xin Guo Hengxing Jiao Tiantian Zhang Yuelin Zhang |
| author_facet | Xin Guo Hengxing Jiao Tiantian Zhang Yuelin Zhang |
| author_sort | Xin Guo |
| collection | DOAJ |
| description | Objective: Although some meta-analyses have shown a correlation between a high neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with gliomas, their conclusions are controversial, and no study has specifically explored the relationship between a high pre-treatment and pre-operative NLR and low survival in patients with glioblastoma (GBM). Therefore, we further investigated this correlation through meta-analysis. Methods: We searched the PubMed, Metstr, and Cochrane databases in March 2022 for published literature related to high pre-treatment and pre-operative NLR and low survival in patients with GBM. The literature was rigorously searched according to inclusion and exclusion criteria to calculate the overall hazard ratio (HR) and 95% confidence interval (CI) corresponding to a high NLR using a random effects model. Results: The total HR for the pre-treatment and pre-operative NLR was 1.46 (95% CI: 1.17–1.75, <i>p</i> = 0.000, I<sup>2</sup> = 76.5%), indicating a significant association between a high pre-treatment and pre-operative NLR, and low overall survival in patients with GBM. Sub-group analysis was performed because of the high heterogeneity. The results for the sub-group with a cut-off value of 4 showed an HR of 1.39 (95% CI: 1.12–1.65, <i>p</i> = 0.000, I<sup>2</sup> = 22.2%), with significantly low heterogeneity, whereas those for the sub-group without a cut-off value of 4 showed an HR of 1.45 (95% CI: 1.01–1.89, <i>p</i> = 0.000, I<sup>2</sup> = 83.3%). Conclusions: The results of this study demonstrate that a high pre-treatment and pre-operative NLR suggests low survival in patients with GBM based on data from a large sample. Furthermore, the meta-regression analysis results indicate that underlying data, such as age and extent of surgical resection, lead to a high degree of heterogeneity, providing a theoretical basis for further research. |
| first_indexed | 2024-03-10T03:14:33Z |
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| id | doaj.art-6ed294519de040b4a9dd938f7ba5eea3 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:33Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-6ed294519de040b4a9dd938f7ba5eea32023-11-23T10:18:50ZengMDPI AGBrain Sciences2076-34252022-05-0112567510.3390/brainsci12050675Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-AnalysisXin Guo0Hengxing Jiao1Tiantian Zhang2Yuelin Zhang3Department of Graduate Work, Hanguang Campus of Xi’an Medical University, Xi’an 710068, ChinaDepartment of Graduate Work, Hanguang Campus of Xi’an Medical University, Xi’an 710068, ChinaDepartment of Graduate Work, Hanguang Campus of Xi’an Medical University, Xi’an 710068, ChinaVice President of Xi’an Medical University, Weiyang Campus of Xi’an Medical University, Xi’an 710068, ChinaObjective: Although some meta-analyses have shown a correlation between a high neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with gliomas, their conclusions are controversial, and no study has specifically explored the relationship between a high pre-treatment and pre-operative NLR and low survival in patients with glioblastoma (GBM). Therefore, we further investigated this correlation through meta-analysis. Methods: We searched the PubMed, Metstr, and Cochrane databases in March 2022 for published literature related to high pre-treatment and pre-operative NLR and low survival in patients with GBM. The literature was rigorously searched according to inclusion and exclusion criteria to calculate the overall hazard ratio (HR) and 95% confidence interval (CI) corresponding to a high NLR using a random effects model. Results: The total HR for the pre-treatment and pre-operative NLR was 1.46 (95% CI: 1.17–1.75, <i>p</i> = 0.000, I<sup>2</sup> = 76.5%), indicating a significant association between a high pre-treatment and pre-operative NLR, and low overall survival in patients with GBM. Sub-group analysis was performed because of the high heterogeneity. The results for the sub-group with a cut-off value of 4 showed an HR of 1.39 (95% CI: 1.12–1.65, <i>p</i> = 0.000, I<sup>2</sup> = 22.2%), with significantly low heterogeneity, whereas those for the sub-group without a cut-off value of 4 showed an HR of 1.45 (95% CI: 1.01–1.89, <i>p</i> = 0.000, I<sup>2</sup> = 83.3%). Conclusions: The results of this study demonstrate that a high pre-treatment and pre-operative NLR suggests low survival in patients with GBM based on data from a large sample. Furthermore, the meta-regression analysis results indicate that underlying data, such as age and extent of surgical resection, lead to a high degree of heterogeneity, providing a theoretical basis for further research.https://www.mdpi.com/2076-3425/12/5/675glioblastomaGBMglioblastoma multiformeNLRneutrophil-to-lymphocyte ratioprognostic |
| spellingShingle | Xin Guo Hengxing Jiao Tiantian Zhang Yuelin Zhang Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis Brain Sciences glioblastoma GBM glioblastoma multiforme NLR neutrophil-to-lymphocyte ratio prognostic |
| title | Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis |
| title_full | Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis |
| title_fullStr | Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis |
| title_full_unstemmed | Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis |
| title_short | Pre-Treatment and Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Prognostic Value of Glioblastoma: A Meta-Analysis |
| title_sort | pre treatment and preoperative neutrophil to lymphocyte ratio predicts prognostic value of glioblastoma a meta analysis |
| topic | glioblastoma GBM glioblastoma multiforme NLR neutrophil-to-lymphocyte ratio prognostic |
| url | https://www.mdpi.com/2076-3425/12/5/675 |
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