Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis
Steroid hormones represent an amazing class of molecules that play pleiotropic roles in vertebrates. In mammals, during postnatal development, sex steroids significantly influence the organization of sexually dimorphic neural circuits underlying behaviors critical for survival, such as the reproduct...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/7984 |
| _version_ | 1797525583819702272 |
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| author | Sara Trova Serena Bovetti Sara Bonzano Silvia De Marchis Paolo Peretto |
| author_facet | Sara Trova Serena Bovetti Sara Bonzano Silvia De Marchis Paolo Peretto |
| author_sort | Sara Trova |
| collection | DOAJ |
| description | Steroid hormones represent an amazing class of molecules that play pleiotropic roles in vertebrates. In mammals, during postnatal development, sex steroids significantly influence the organization of sexually dimorphic neural circuits underlying behaviors critical for survival, such as the reproductive one. During the last decades, multiple studies have shown that many cortical and subcortical brain regions undergo sex steroid-dependent structural organization around puberty, a critical stage of life characterized by high sensitivity to external stimuli and a profound structural and functional remodeling of the organism. Here, we first give an overview of current data on how sex steroids shape the peripubertal brain by regulating neuroplasticity mechanisms. Then, we focus on adult neurogenesis, a striking form of persistent structural plasticity involved in the control of social behaviors and regulated by a fine-tuned integration of external and internal cues. We discuss recent data supporting that the sex steroid-dependent peripubertal organization of neural circuits involves a sexually dimorphic set-up of adult neurogenesis that in turn could be relevant for sex-specific reproductive behaviors. |
| first_indexed | 2024-03-10T09:14:58Z |
| format | Article |
| id | doaj.art-6ed2c27cfaf9424fb607ff088b40b372 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:14:58Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6ed2c27cfaf9424fb607ff088b40b3722023-11-22T05:41:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012215798410.3390/ijms22157984Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult NeurogenesisSara Trova0Serena Bovetti1Sara Bonzano2Silvia De Marchis3Paolo Peretto4Department of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, ItalyDepartment of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, ItalyDepartment of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, ItalyDepartment of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, ItalyDepartment of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, ItalySteroid hormones represent an amazing class of molecules that play pleiotropic roles in vertebrates. In mammals, during postnatal development, sex steroids significantly influence the organization of sexually dimorphic neural circuits underlying behaviors critical for survival, such as the reproductive one. During the last decades, multiple studies have shown that many cortical and subcortical brain regions undergo sex steroid-dependent structural organization around puberty, a critical stage of life characterized by high sensitivity to external stimuli and a profound structural and functional remodeling of the organism. Here, we first give an overview of current data on how sex steroids shape the peripubertal brain by regulating neuroplasticity mechanisms. Then, we focus on adult neurogenesis, a striking form of persistent structural plasticity involved in the control of social behaviors and regulated by a fine-tuned integration of external and internal cues. We discuss recent data supporting that the sex steroid-dependent peripubertal organization of neural circuits involves a sexually dimorphic set-up of adult neurogenesis that in turn could be relevant for sex-specific reproductive behaviors.https://www.mdpi.com/1422-0067/22/15/7984pubertygonadal hormonesadult neurogenesissexual dimorphismpheromones |
| spellingShingle | Sara Trova Serena Bovetti Sara Bonzano Silvia De Marchis Paolo Peretto Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis International Journal of Molecular Sciences puberty gonadal hormones adult neurogenesis sexual dimorphism pheromones |
| title | Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis |
| title_full | Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis |
| title_fullStr | Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis |
| title_full_unstemmed | Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis |
| title_short | Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis |
| title_sort | sex steroids and the shaping of the peripubertal brain the sexual dimorphic set up of adult neurogenesis |
| topic | puberty gonadal hormones adult neurogenesis sexual dimorphism pheromones |
| url | https://www.mdpi.com/1422-0067/22/15/7984 |
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