Clonality, Mutation and Kaposi Sarcoma: A Systematic Review
Background: It remains uncertain whether Kaposi sarcoma (KS) is a true neoplasm, in that it regresses after removal of the stimulus to growth (as HHV8) when immunosuppression is reduced. We aimed to summarize the available evidence on somatic mutations and clonality within KS to assess whether KS is...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/5/1201 |
| _version_ | 1797475479775608832 |
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| author | Blanca Iciar Indave Ruiz Subasri Armon Reiko Watanabe Lesley Uttley Valerie A. White Alexander J. Lazar Ian A. Cree |
| author_facet | Blanca Iciar Indave Ruiz Subasri Armon Reiko Watanabe Lesley Uttley Valerie A. White Alexander J. Lazar Ian A. Cree |
| author_sort | Blanca Iciar Indave Ruiz |
| collection | DOAJ |
| description | Background: It remains uncertain whether Kaposi sarcoma (KS) is a true neoplasm, in that it regresses after removal of the stimulus to growth (as HHV8) when immunosuppression is reduced. We aimed to summarize the available evidence on somatic mutations and clonality within KS to assess whether KS is a neoplasm or not. Methods: Medline and Web of Science were searched until September 2020 for articles on clonality or mutation in KS. Search strings were supervised by expert librarians, and two researchers independently performed study selection and data extraction. An adapted version of the QUADAS2 tool was used for methodological quality appraisal. Results: Of 3077 identified records, 20 publications reported on relevant outcomes and were eligible for qualitative synthesis. Five studies reported on clonality, 10 studies reported on various mutations, and 5 studies reported on chromosomal aberrations in KS. All studies were descriptive and were judged to have a high risk of bias. There was considerable heterogeneity of results with respect to clonality, mutation and cytogenetic abnormalities as well as in terms of types of lesions and patient characteristics. Conclusions: While KS certainly produces tumours, the knowledge is currently insufficient to determine whether KS is a clonal neoplasm (sarcoma), or simply an aggressive reactive virus-driven lesion. |
| first_indexed | 2024-03-09T20:45:42Z |
| format | Article |
| id | doaj.art-6ed5ebdade854fb5bfbb107344042398 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:45:42Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6ed5ebdade854fb5bfbb1073440423982023-11-23T22:47:20ZengMDPI AGCancers2072-66942022-02-01145120110.3390/cancers14051201Clonality, Mutation and Kaposi Sarcoma: A Systematic ReviewBlanca Iciar Indave Ruiz0Subasri Armon1Reiko Watanabe2Lesley Uttley3Valerie A. White4Alexander J. Lazar5Ian A. Cree6International Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, FranceInternational Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, FranceInternational Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, FranceSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield S1 4DA, UKInternational Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, FranceDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAInternational Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, FranceBackground: It remains uncertain whether Kaposi sarcoma (KS) is a true neoplasm, in that it regresses after removal of the stimulus to growth (as HHV8) when immunosuppression is reduced. We aimed to summarize the available evidence on somatic mutations and clonality within KS to assess whether KS is a neoplasm or not. Methods: Medline and Web of Science were searched until September 2020 for articles on clonality or mutation in KS. Search strings were supervised by expert librarians, and two researchers independently performed study selection and data extraction. An adapted version of the QUADAS2 tool was used for methodological quality appraisal. Results: Of 3077 identified records, 20 publications reported on relevant outcomes and were eligible for qualitative synthesis. Five studies reported on clonality, 10 studies reported on various mutations, and 5 studies reported on chromosomal aberrations in KS. All studies were descriptive and were judged to have a high risk of bias. There was considerable heterogeneity of results with respect to clonality, mutation and cytogenetic abnormalities as well as in terms of types of lesions and patient characteristics. Conclusions: While KS certainly produces tumours, the knowledge is currently insufficient to determine whether KS is a clonal neoplasm (sarcoma), or simply an aggressive reactive virus-driven lesion.https://www.mdpi.com/2072-6694/14/5/1201KaposisarcomaclonalityreactiveDNAHHV8 |
| spellingShingle | Blanca Iciar Indave Ruiz Subasri Armon Reiko Watanabe Lesley Uttley Valerie A. White Alexander J. Lazar Ian A. Cree Clonality, Mutation and Kaposi Sarcoma: A Systematic Review Cancers Kaposi sarcoma clonality reactive DNA HHV8 |
| title | Clonality, Mutation and Kaposi Sarcoma: A Systematic Review |
| title_full | Clonality, Mutation and Kaposi Sarcoma: A Systematic Review |
| title_fullStr | Clonality, Mutation and Kaposi Sarcoma: A Systematic Review |
| title_full_unstemmed | Clonality, Mutation and Kaposi Sarcoma: A Systematic Review |
| title_short | Clonality, Mutation and Kaposi Sarcoma: A Systematic Review |
| title_sort | clonality mutation and kaposi sarcoma a systematic review |
| topic | Kaposi sarcoma clonality reactive DNA HHV8 |
| url | https://www.mdpi.com/2072-6694/14/5/1201 |
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