The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension
The HIV-infected population is at a dramatically increased risk of developing pulmonary arterial hypertension (PAH), a devastating and fatal cardiopulmonary disease that is rare amongst the general population. It is increasingly apparent that PAH is a disease with complex and heterogeneous cellular...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3305 |
| _version_ | 1797568609914978304 |
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| author | Ari Simenauer Eva Nozik-Grayck Adela Cota-Gomez |
| author_facet | Ari Simenauer Eva Nozik-Grayck Adela Cota-Gomez |
| author_sort | Ari Simenauer |
| collection | DOAJ |
| description | The HIV-infected population is at a dramatically increased risk of developing pulmonary arterial hypertension (PAH), a devastating and fatal cardiopulmonary disease that is rare amongst the general population. It is increasingly apparent that PAH is a disease with complex and heterogeneous cellular and molecular pathologies, and options for therapeutic intervention are limited, resulting in poor clinical outcomes for affected patients. A number of soluble HIV factors have been implicated in driving the cellular pathologies associated with PAH through perturbations of various signaling and regulatory networks of uninfected bystander cells in the pulmonary vasculature. While these mechanisms are likely numerous and multifaceted, the overlapping features of PAH cellular pathologies and the effects of viral factors on related cell types provide clues as to the potential mechanisms driving HIV-PAH etiology and progression. In this review, we discuss the link between the DNA damage response (DDR) signaling network, chronic HIV infection, and potential contributions to the development of pulmonary arterial hypertension in chronically HIV-infected individuals. |
| first_indexed | 2024-03-10T19:59:23Z |
| format | Article |
| id | doaj.art-6ed7cffb41114f08b634af9512c81d26 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:59:23Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6ed7cffb41114f08b634af9512c81d262023-11-19T23:41:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01219330510.3390/ijms21093305The DNA Damage Response and HIV-Associated Pulmonary Arterial HypertensionAri Simenauer0Eva Nozik-Grayck1Adela Cota-Gomez2Department of Medicine Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USACardiovascular Pulmonary Research Labs and Pediatric Critical Care Medicine, University of Colorado Denver, Pediatric Critical Care Medicine, Aurora, CO 80045, USADepartment of Medicine Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USAThe HIV-infected population is at a dramatically increased risk of developing pulmonary arterial hypertension (PAH), a devastating and fatal cardiopulmonary disease that is rare amongst the general population. It is increasingly apparent that PAH is a disease with complex and heterogeneous cellular and molecular pathologies, and options for therapeutic intervention are limited, resulting in poor clinical outcomes for affected patients. A number of soluble HIV factors have been implicated in driving the cellular pathologies associated with PAH through perturbations of various signaling and regulatory networks of uninfected bystander cells in the pulmonary vasculature. While these mechanisms are likely numerous and multifaceted, the overlapping features of PAH cellular pathologies and the effects of viral factors on related cell types provide clues as to the potential mechanisms driving HIV-PAH etiology and progression. In this review, we discuss the link between the DNA damage response (DDR) signaling network, chronic HIV infection, and potential contributions to the development of pulmonary arterial hypertension in chronically HIV-infected individuals.https://www.mdpi.com/1422-0067/21/9/3305HIVpulmonary arterial hypertensionendothelialDNA damageTatNef |
| spellingShingle | Ari Simenauer Eva Nozik-Grayck Adela Cota-Gomez The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension International Journal of Molecular Sciences HIV pulmonary arterial hypertension endothelial DNA damage Tat Nef |
| title | The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension |
| title_full | The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension |
| title_fullStr | The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension |
| title_full_unstemmed | The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension |
| title_short | The DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension |
| title_sort | dna damage response and hiv associated pulmonary arterial hypertension |
| topic | HIV pulmonary arterial hypertension endothelial DNA damage Tat Nef |
| url | https://www.mdpi.com/1422-0067/21/9/3305 |
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