Photosensitizing Antivirals
Antiviral action of various photosensitizers is already summarized in several comprehensive reviews, and various mechanisms have been proposed for it. However, a critical consideration of the matter of the area is complicated, since the exact mechanisms are very difficult to explore and clarify, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3971 |
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| author | Kseniya A. Mariewskaya Anton P. Tyurin Alexey A. Chistov Vladimir A. Korshun Vera A. Alferova Alexey V. Ustinov |
| author_facet | Kseniya A. Mariewskaya Anton P. Tyurin Alexey A. Chistov Vladimir A. Korshun Vera A. Alferova Alexey V. Ustinov |
| author_sort | Kseniya A. Mariewskaya |
| collection | DOAJ |
| description | Antiviral action of various photosensitizers is already summarized in several comprehensive reviews, and various mechanisms have been proposed for it. However, a critical consideration of the matter of the area is complicated, since the exact mechanisms are very difficult to explore and clarify, and most publications are of an empirical and “phenomenological” nature, reporting a dependence of the antiviral action on illumination, or a correlation of activity with the photophysical properties of the substances. Of particular interest is substance-assisted photogeneration of highly reactive singlet oxygen (<sup>1</sup>O<sub>2</sub>). The damaging action of <sup>1</sup>O<sub>2</sub> on the lipids of the viral envelope can probably lead to a loss of the ability of the lipid bilayer of enveloped viruses to fuse with the lipid membrane of the host cell. Thus, lipid bilayer-affine <sup>1</sup>O<sub>2</sub> photosensitizers have prospects as broad-spectrum antivirals against enveloped viruses. In this short review, we want to point out the main types of antiviral photosensitizers with potential affinity to the lipid bilayer and summarize the data on new compounds over the past three years. Further understanding of the data in the field will spur a targeted search for substances with antiviral activity against enveloped viruses among photosensitizers able to bind to the lipid membranes. |
| first_indexed | 2024-03-09T04:44:58Z |
| format | Article |
| id | doaj.art-6ed7e23fa1fb413f8336779457a58d9c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:44:58Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6ed7e23fa1fb413f8336779457a58d9c2023-12-03T13:16:16ZengMDPI AGMolecules1420-30492021-06-012613397110.3390/molecules26133971Photosensitizing AntiviralsKseniya A. Mariewskaya0Anton P. Tyurin1Alexey A. Chistov2Vladimir A. Korshun3Vera A. Alferova4Alexey V. Ustinov5Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, RussiaAntiviral action of various photosensitizers is already summarized in several comprehensive reviews, and various mechanisms have been proposed for it. However, a critical consideration of the matter of the area is complicated, since the exact mechanisms are very difficult to explore and clarify, and most publications are of an empirical and “phenomenological” nature, reporting a dependence of the antiviral action on illumination, or a correlation of activity with the photophysical properties of the substances. Of particular interest is substance-assisted photogeneration of highly reactive singlet oxygen (<sup>1</sup>O<sub>2</sub>). The damaging action of <sup>1</sup>O<sub>2</sub> on the lipids of the viral envelope can probably lead to a loss of the ability of the lipid bilayer of enveloped viruses to fuse with the lipid membrane of the host cell. Thus, lipid bilayer-affine <sup>1</sup>O<sub>2</sub> photosensitizers have prospects as broad-spectrum antivirals against enveloped viruses. In this short review, we want to point out the main types of antiviral photosensitizers with potential affinity to the lipid bilayer and summarize the data on new compounds over the past three years. Further understanding of the data in the field will spur a targeted search for substances with antiviral activity against enveloped viruses among photosensitizers able to bind to the lipid membranes.https://www.mdpi.com/1420-3049/26/13/3971broad-spectrum antiviralsphotosensitizationlipid bilayersinglet oxygenhypericinperylene derivatives |
| spellingShingle | Kseniya A. Mariewskaya Anton P. Tyurin Alexey A. Chistov Vladimir A. Korshun Vera A. Alferova Alexey V. Ustinov Photosensitizing Antivirals Molecules broad-spectrum antivirals photosensitization lipid bilayer singlet oxygen hypericin perylene derivatives |
| title | Photosensitizing Antivirals |
| title_full | Photosensitizing Antivirals |
| title_fullStr | Photosensitizing Antivirals |
| title_full_unstemmed | Photosensitizing Antivirals |
| title_short | Photosensitizing Antivirals |
| title_sort | photosensitizing antivirals |
| topic | broad-spectrum antivirals photosensitization lipid bilayer singlet oxygen hypericin perylene derivatives |
| url | https://www.mdpi.com/1420-3049/26/13/3971 |
| work_keys_str_mv | AT kseniyaamariewskaya photosensitizingantivirals AT antonptyurin photosensitizingantivirals AT alexeyachistov photosensitizingantivirals AT vladimirakorshun photosensitizingantivirals AT veraaalferova photosensitizingantivirals AT alexeyvustinov photosensitizingantivirals |