A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for ada...
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Bibliographic Details
| Main Authors: |
Lei Yuan,
Gary C. Chan,
David Beeler,
Lauren Janes,
Katherine C. Spokes,
Harita Dharaneeswaran,
Anahita Mojiri,
William J. Adams,
Tracey Sciuto,
Guillermo Garcia-Cardeña,
Grietje Molema,
Peter M. Kang,
Nadia Jahroudi,
Philip A. Marsden,
Ann Dvorak,
Erzsébet Ravasz Regan,
William C. Aird |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10160
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