A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for ada...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10160 |
| _version_ | 1818716851491831808 |
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| author | Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird |
| author_facet | Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird |
| author_sort | Lei Yuan |
| collection | DOAJ |
| description | Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis. |
| first_indexed | 2024-12-17T19:25:50Z |
| format | Article |
| id | doaj.art-6ed9333a2a8b469cb9f3182d7d55819d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:25:50Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6ed9333a2a8b469cb9f3182d7d55819d2022-12-21T21:35:23ZengNature PortfolioNature Communications2041-17232016-01-017111610.1038/ncomms10160A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneityLei Yuan0Gary C. Chan1David Beeler2Lauren Janes3Katherine C. Spokes4Harita Dharaneeswaran5Anahita Mojiri6William J. Adams7Tracey Sciuto8Guillermo Garcia-Cardeña9Grietje Molema10Peter M. Kang11Nadia Jahroudi12Philip A. Marsden13Ann Dvorak14Erzsébet Ravasz Regan15William C. Aird16Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, University of AlbertaDepartment of Pathology, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Pathology, Center for Excellence in Vascular Biology, Brigham and Women's HospitalDepartment of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of GroningenDepartment of Medicine, Beth Israel Deaconess Medical CenterDepartment of Medicine, University of AlbertaDepartment of Medicine, University of TorontoDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterDepartment of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical CenterSpontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis.https://doi.org/10.1038/ncomms10160 |
| spellingShingle | Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity Nature Communications |
| title | A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| title_full | A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| title_fullStr | A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| title_full_unstemmed | A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| title_short | A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| title_sort | role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity |
| url | https://doi.org/10.1038/ncomms10160 |
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